Results 91 to 100 of about 253,176 (288)
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, EarlyView.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Protecting Directors and Officers from Liability Arising from Aggressive Earnings Management [PDF]
A lingering topic in corporate governance is whether corporate directors should be protected against shareholder lawsuits and whether such protection reduces the incentives of directors to monitor appropriately the behaviour of corporate officers.
Amandine Hanon, M. Martin Boyer
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British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
Tax Buoyancy Effect Of Direct Taxes In Turkey
Gümrük ve Ticaret Dergisi, 2022 The study aims to examine the buoyancy effect of direct taxes in Turkey. While analyzing the buoyancy effect of direct taxes, personal income tax and corporate tax, including direct tax revenues, are considered.
Pınar Bengi Kaya +1 more
doaj
The Remedial Action of the "State of Capture" Report in Perspective
Potchefstroom Electronic Law Journal, 2017 In the State of Capture report the public protector instructed the president to appoint a commission of inquiry to investigate the capture of state institutions by the Gupta family.
Loammi Wolf
doaj +1 more source
Who and how should participate in health care priority setting? Evidence from a Portuguese survey [PDF]
This article provides highlights of the evolution of the health care rationing debate towards a more transparent and open approach involving public participation. Discretionary models that have dominated health sector decision-making are being questioned
Anabela Botelho +2 more
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Evaluation of the 16-19 Bursary Fund: year 1 report [PDF]
, 2013 Key Findings: The total number of young people in England receiving a Defined Vulnerable Group (DVG) Bursary in 2011/12 is estimated to be 27,400. The total number of students awarded Discretionary Bursaries in 2011/12 in England is estimated to be ...
Callanan, Meg +4 more
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British Journal of Clinical Pharmacology, EarlyView.Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang +7 more
wiley +1 more source
The Role of Discretion in Professional Practice
Annales Etyka w Życiu Gospodarczym, 2016 Various scholars of ethics and economics conduct research on the best modes of decision making which guarantee good outcome and moral behaviour of the individuals involved. Either of the modes considered, rules with regulations or discretion and judgment,
Piotr Wajszczyk
doaj +1 more source
Differential Informativeness of Accrual Measures to Analysts’ Forecast Accuracy [PDF]
, 2020 This paper evaluates whether analysts incorporate formal measures of earnings quality into their earnings forecasts. It examines whether the accrual ratio and abnormal accruals, measured with the Modified Jones (1991) Model of discretionary accruals ...
Asare, Kwadwo +2 more
core +1 more source