Results 121 to 130 of about 245,976 (321)

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function.
Emma Dohmann   +5 more
wiley   +1 more source

Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.
Non Davies   +3 more
wiley   +1 more source

Effect of vepdegestrant, a PROTAC oestrogen receptor degrader, on dabigatran and rosuvastatin pharmacokinetics in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effects of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) oestrogen receptor degrader, on the pharmacokinetics of dabigatran (a P‐glycoprotein [P‐gp] substrate) and rosuvastatin (a breast cancer resistance protein [BCRP] substrate).
Derek Z. Yang   +9 more
wiley   +1 more source

European public finances under pressure?. [PDF]

open access: yes
This paper should be read as complementary to my last briefing paper (N3, September 2001) The European policy mix At its meeting on 8 November, the Governing Council of the ECB decided to reduce the minimum bid rate on the main refinancing operations of ...
Fitoussi, Jean-Paul
core  

Navigating adverse immunostimulation: A practical guide for clinical researchers

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort   +3 more
wiley   +1 more source

Discretionary Decision Making in the Management of Human Service Organizations [PDF]

open access: yes, 1987
The University Archives has determined that this item is of continuing value to OSU's history.Presenter: Therese J. Dent, Ph.D., Diplomate Clinical Social Worker, Lakeside Center, Adjunct Assistant Professor, St. Louis University, St.
Dent, Therese J.
core  

Graduates' conceptions of meaningful work

open access: yesBritish Educational Research Journal, EarlyView.
Abstract This paper explores how meaningful work is conceptualised by recent graduates. Whilst the imperative to maximise economic returns from higher education (HE) endures in HE policy, less attention is given to how meaningful work is and its relationship to values and identities.
Michael Tomlinson, Manuel Souto‐Otero
wiley   +1 more source

Teachers', parents', and pupils' perceptions and described experiences of toilet provisions and practices within English schools

open access: yesBritish Educational Research Journal, EarlyView.
Abstract This paper explores teachers', parents' and pupils' perceptions and described experiences of school toilet policies, provisions and practices within state‐funded primary (5–11 years) and secondary (11–16 years) schools in England. In doing so, this research critically examines how school‐specific policies and toilet provisions influence ...
Matthew J. Green   +3 more
wiley   +1 more source

Sexual Assault Case Processing: A Descriptive Model of Attrition and Decision Making [PDF]

open access: yes, 2006
The outcomes of sexual assaults involving one suspect and one victim reported to the Anchorage Police Department (APD) in 2000 to 2003 were examined.
Snodgrass, G. Matthew
core   +1 more source

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