Results 71 to 80 of about 580,173 (268)

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

open access: yesAdvanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su   +16 more
wiley   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

open access: yesAdvanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun   +7 more
wiley   +1 more source

DISCRIMINANT ANALYSIS IN MARKETING RESEARCH [PDF]

open access: yesManagement & Marketing, 2010
This paper classifies among marketing researches aiming to study the influence that the following independent variables (explanatory) have: "Estimating the expenses incurred in Centre Development Region, including country of residence" and the variable ...
Erika KULCSÁR
doaj  

Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes

open access: yesAdvanced Science, EarlyView.
Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji   +12 more
wiley   +1 more source

LGOH-Based Discriminant Centre-Surround Saliency Detection

open access: yesInternational Journal of Advanced Robotic Systems, 2013
Discriminant saliency is a kind of decision-theoretic-based saliency detection method that has been proposed recently. Based on local gradient distribution, this paper proposes a simple but efficient discriminant centre-surround hypothesis, and builds ...
Lili Lin, Wenhui Zhou
doaj   +1 more source

Dimension Reduction by Mutual Information Discriminant Analysis [PDF]

open access: yes, 2012
In the past few decades, researchers have proposed many discriminant analysis (DA) algorithms for the study of high-dimensional data in a variety of problems.
Shadvar, Ali
core   +1 more source

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu   +6 more
wiley   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

open access: yesAdvanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao   +13 more
wiley   +1 more source

Modelos de Previsión del Fracaso Empresarial: ¿Funciona Entre Nuestras Empresas el Modelo de Altman de 1968?

open access: yesRevista de Contabilidad: Spanish Accounting Review, 1998
El modelo discriminante de Altman (1968) ha sido muchas veces propuesto como herramienta válida de predicción en los dos años previos al fracaso de la empresa.
Fermín Lizarraga Dallo
doaj  

Locality-Preserving Multiprojection Discriminant Analysis

open access: yesMathematics
Linear discriminant analysis (LDA), as an effective feature extraction method, has been widely applied in high-dimensional data analysis. However, its discriminative performance is still severely limited by the following factors.
Jiajun Ma
doaj   +1 more source

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