Results 51 to 60 of about 4,899,143 (307)

Noise Discrimination Factor and Noise Discrimination Index: Concepts for Discussion [PDF]

open access: yesThe Journal of the Acoustical Society of America, 1951
The importance of intelligible communication in noise has focused attention on noise-canceling microphones, and one of the attendant problems is that of assigning valid figures of merit to such microphones for the purpose of comparing their noise-canceling properties.
openaire   +1 more source

Obesity, perceived weight discrimination, and psychological well-being in older adults in England [PDF]

open access: yes, 2015
Objective To examine whether the adverse effect of obesity on psychological well-being can be explained by weight discrimination. Methods The study sample included 5056 older (≥50 y) men and women living in England and participating in the English ...
Beeken, RJ, Jackson, SE, Wardle, J
core  

Discrimination performance of PFAA index.

open access: yes, 2015
a: Following PFAAs was used as variables: Ser, Asn, Ile, Ala, His, and Trp.Discrimination performance of PFAA index.
Nobuyasu Fukutake (764554)   +12 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

ON THE DISCRIMINANT AND INDEX OF A CERTAIN CLASS OF POLYNOMIALS

open access: yesBulletin of the Australian Mathematical Society
Abstract Let $f(x) = (x^{2}+1)^{n} - ax^{n} \in \mathbb {Z}[x]$ and assume
RUPAM BARMAN, ANUJ NARODE, VINAY WAGH
openaire   +2 more sources

The concordance index (c-index) yielded by AUC to evaluate the predictive discrimination of the nomograms.

open access: yes, 2016
The concordance index (c-index) yielded by AUC to evaluate the predictive discrimination of the nomograms.
Seung Beom Ha (2148469)   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

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