Results 41 to 50 of about 5,084 (166)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging. [PDF]

PLoS ONE, 2018
BACKGROUND:Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and
Tao Han Lee, Cheng-Chia Lee, Chau-Yee Ng, Ming-Yang Chang, Su-Wei Chang, Pei-Chun Fan, Wen-Hung Chung, Ya-Chung Tian, Yung-Chang Chen, Chih-Hsiang Chang   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Agreement and Discriminative Ability of the Intrinsic Capacity Tool-10 among Older Adults in Northern India

Journal of the Indian Academy of Geriatrics
Background: Intrinsic capacity (IC) underpins the World Health Organization healthy aging framework, yet comprehensive IC assessment is often impractical in routine outpatient care.
Swarup Das, Akshata Rao, Abhijith Rajaram Rao, Venugopal Mantry, Maroof Ahmad Khan, Avinash Chakrawarty, Naveet Wig, Prasun Chatterjee   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Discriminative Ability of FRAX and Possible FRAX-based Intervention Thresholds for Beijing-dwelling People [PDF]

Zhongguo quanke yixue
Background The overall diagnosis and treatment rate of osteoporotic fractures is low in our county, and there is an urgent need to find reliable prediction tools.
LIU Yangxiaoou, SUN Yange, YU Su, DU Xueping, HUANG Kai, YAN Yan, LI Chao
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Correlation between uric acid/high-density lipoprotein cholesterol ratio and carotid plaque formation: A retrospective cross-sectional study in Anhui's health check-up population

Experimental Gerontology
Background: This study examines the uric acid to high-density lipoprotein cholesterol ratio (UHR) and carotid plaque formation in a health examination cohort to explore its association with early atherosclerosis and its discriminative ability for carotid
Xiaoyu Zhang, Tianrui Liu, Yujuan Lei, Qifan Zhao, Yu Chang, Huaqing Hu   +5 more
doaj   +1 more source

An Electronic Nose for Reliable Measurement and Correct Classification of Beverages

Sensors, 2011
This paper reports the design of an electronic nose (E-nose) prototype for reliable measurement and correct classification of beverages. The prototype was developed and fabricated in the laboratory using commercially available metal oxide gas sensors and
Mahammad A. Hannan, Salina Abdul Samad, Mazlina Mamat   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source