Results 51 to 60 of about 97,758 (297)

Discriminative ability of functional loading tests for adolescent jumper's knee

, 2003
Objective. To investigate the reliability and validity of five squat-based loading tests that are clinically appropriate for jumper's knee. The loading tests were step up, double leg squat, double leg squat on a 25-degree decline (decline squat), single ...
Khan, Karim M., Cook, Jill L., Hopper, Diana M., Griffiths, Lyn R., Purdam, Craig R.   +4 more
core   +1 more source

Discriminative ability of reflex receptive fields to distinguish patients with acute and chronic low back pain [PDF]

, 2016
Low back pain has a life time prevalence of 70-85%. 10-20% of all patients experience recurrent episodes or develop chronic low back pain. Socio-demographic, clinical and psychological characteristics explain the transition from acute to chronic low back
Andersen, Ole Kæseler; id_orcid, Peter Jüni, Paul Heini, Müller, Monika, Jüni, Peter, Agten, Christoph A., José A. Biurrun Manresa, Agten, Christoph A, Heini, Paul, Treichel, Fabienne, Biurrun Manresa, José Alberto, Ole K. Andersen, Andersen, Ole K., Agten , Christoph Amadeus, Andersen, Ole K, Fabienne Treichel, Michele Curatolo, Biurrun Manresa, José, Monika Müller, Curatolo, Michele, Biurrun Manresa, José A, Christoph A. Agten   +21 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Discriminative ability of the WAI dimensions in the prediction of different durations of sickness absence among office workers (n = 1,331).

, 2015
*p-value
Maurice A. J. Niessen (745789), Yvonne Vergouwe (52606), Kerstin G. Reeuwijk (745787), Suzan J. W. Robroek (745788), Alex Burdorf (15654), Roderik A. Kraaijenhagen (745790)   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of working memory in children's ability for prosodic discrimination

PLOS ONE, 2020
Previous research established that young children are sensitive to prosodic cues discriminating between syntactic structures of otherwise similarly sounding sentences in a language unknown to them. In this study, we explore the role of working memory that children might deploy for the purpose of the sentence-level prosodic discrimination. Nine-year old
Arthur Stepanov, Karmen Brina Kodrič, Penka Stateva   +2 more
openaire   +4 more sources

Property of discriminative ability of individual scores in predicting in-hospital mortality.

, 2018
Property of discriminative ability of individual scores in predicting in-hospital mortality.
Chau-Yee Ng (5729000), Ya-Chung Tian (295345), Yung-Chang Chen (295353), Wen-Hung Chung (2448931), Chih-Hsiang Chang (295343), Ming-Yang Chang (295344), Pei-Chun Fan (295342), Su-Wei Chang (231505), Tao Han Lee (5728997), Cheng-Chia Lee (440388)   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source