Results 71 to 80 of about 97,758 (297)
The Discriminative Ability of FRAX and Possible FRAX-based Intervention Thresholds for Beijing-dwelling People [PDF]
Zhongguo quanke yixueBackground The overall diagnosis and treatment rate of osteoporotic fractures is low in our county, and there is an urgent need to find reliable prediction tools.
LIU Yangxiaoou, SUN Yange, YU Su, DU Xueping, HUANG Kai, YAN Yan, LI Chao
doaj +1 more source
Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies
, 2014 There has long been need for a behavioural intervention that attenuates cue-evoked drug-seeking, but the optimal method remains obscure. To address this, we report three approaches to extinguish cue-evoked drug-seeking measured in a Pavlovian to ...
Rose, Abigail K. +32 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Experimental GerontologyBackground: This study examines the uric acid to high-density lipoprotein cholesterol ratio (UHR) and carotid plaque formation in a health examination cohort to explore its association with early atherosclerosis and its discriminative ability for carotid
Xiaoyu Zhang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Improving GNN Calibration with Discriminative Ability: Insights and Strategies
The widespread adoption of Graph Neural Networks (GNNs) has led to an increasing focus on their reliability. To address the issue of underconfidence in GNNs, various calibration methods have been developed to gain notable reductions in calibration error.
Chen, Qianyu +3 more
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Fluid Abilities and Rule Learning: Patterning and Biconditional Discriminations [PDF]
Journal of Intelligence, 2018 Previous experience with discrimination problems that can only be solved by learning about stimulus configurations enhances performance on new configural discriminations. Some of these effects can be explained by a shift toward increased configural processing (learning about combinations of cues rather than about individual elements), or by a tendency ...
Irina Baetu +3 more
openaire +4 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source