Results 91 to 100 of about 1,967,846 (356)

Long-term disease-free survival of patients with radically resected thymomas: relevance of cell-cycle protein expression [PDF]

, 2005
BACKGROUND. Despite radical Surgical resection, thymomas often recur. The objective of the current retrospective Study was to investigate the prognostic relevance of the expression of cell-cycle proteins in these neoplasms to formulate a possible ...
Ambrogi, V, Baldi, A, Mineo, D, Mineo, T
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Inferences for current chronic graft-versus-host-disease free and relapse free survival

BMC Medical Research Methodology, 2022
This paper provides the methodologies of a new summary curve that measures the dynamic outcome following allogenic hematopoietic cell transplantation.
Xu Zhang, Scott R. Solomon, Connie Sizemore   +2 more
doaj   +1 more source

Methylation status of Wnt signaling pathway genes affects the clinical outcome of Philadelphia-positive acute lymphoblastic leukemia [PDF]

, 2008
The clinical significance of aberrant promoter methylation of the canonical Wnt pathway antagonist genes (sFRP1, sFRP2, sFRP4, sFRP5, Wif1, Dkk3, and Hdpr1) and also putative tumor-suppressor gene Wnt5a, belonging to the non-canonical Wnt signaling ...
Agirre-Ena, X. (Xabier), Castillejo, J.A. (J.A.), Cordeu, L. (Lucía), Garate, L. (Leire), Heiniger, A. (A.), Jimenez-Velasco, A. (A.), Martin, V. (Vanesa), Prosper, F. (Felipe), Roman-Gomez, J. (José), San-Jose, E. (Edurne), Torres, A. (Antonio), Vilas, A. (Amaia)   +11 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort. [PDF]

, 2016
Purpose Treatment with pembrolizumab, an anti-programmed death-1 antibody, at 10 mg/kg administered once every 2 weeks, displayed durable antitumor activity in programmed death-ligand 1 (PD-L1) -positive recurrent and/or metastatic (R/M) head and neck ...
Berger, Raanan, Burtness, Barbara, Cheng, Jonathan D, Chow, Laura QM, Chung, Hyun Cheol, Dolled-Filhart, Marisa, Eder, Joseph Paul, Geva, Ravit, Gupta, Shilpa, Haddad, Robert, Kang, Hyunseok, Keam, Bhumsuk, Lee, Se-Hoon, Lin, Chia-Chi, Mahipal, Amit, Mehra, Ranee, Meister, Amy, Muro, Kei, Pathiraja, Kumudu, Seiwert, Tanguy Y, Tahara, Makoto, Weiss, Jared   +21 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Adherence to endocrine therapy and its relation to disease‐free survival among breast cancer patients visiting an out‐patient clinic at Khartoum Oncology Hospital, Sudan [PDF]

, 2020
Kamal Eldein Hamed Mohamed, Amany Elamin
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Risk of regional recurrence in triple-negative breast cancer patients: a Dutch cohort study [PDF]

, 2016
Triple-negative breast cancer is associated with early recurrence and low survival rates. Several trials investigate the safety of a more conservative approach of axillary treatment in clinically T1-2N0 breast cancer.
Boer, Maaike de, Duijsens, Gaston H.N.M., Lobbes, Marc B.I., Roozendaal, Lori M. van, Siesling, Sabine, Smidt, Marjolein L., Smit, Leonie H.M., Vries, Bart de, Wilt, Johannes H.W. de   +8 more
core   +5 more sources