Results 91 to 100 of about 1,961,991 (306)

Inferences for current chronic graft-versus-host-disease free and relapse free survival

BMC Medical Research Methodology, 2022
This paper provides the methodologies of a new summary curve that measures the dynamic outcome following allogenic hematopoietic cell transplantation.
Xu Zhang, Scott R. Solomon, Connie Sizemore   +2 more
doaj   +1 more source

Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer. [PDF]

, 2018
The introduction of serum Prostate Specific Antigen (PSA) testing nearly 30 years ago has been associated with a significant shift towards localized disease and decreased deaths due to prostate cancer.
Auman, Heidi, Brooks, James D, Carroll, Peter R, Fazli, Ladan, Feng, Ziding, Gleave, Martin E, Hurtado-Coll, Antonio, Leach, Robin J, Lin, Daniel W, McKenney, Jesse K, Nelson, Peter S, Sahoo, Debashis, Simko, Jeff, Thompson, Ian M, Troyer, Dean A, True, Lawrence D, Wei, Wei   +16 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Influence of perineural invasion in predicting overall survival and disease-free survival in patients With locally advanced gastric cancer [PDF]

, 2017
Background The aim of the present study was to evaluate the prognostic significance of perineural invasion (PNI) in locally advanced gastric cancer patients who underwent D2 gastrectomy and adjuvant chemotherapy.
Aurello, P, Berardi, G, Giulitti, D, Laracca, Gg, Pilozzi, E, Ramacciato, G., RAMPIONI VINCIGUERRA, GIAN LUCA, Socciarelli, F, Tierno, Sm   +8 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: An open-label, 2 × 2 factorial, randomised phase 3 trial [PDF]

, 2015
Background: Whether addition of fluorouracil to epirubicin, cyclophosphamide, and paclitaxel (EC-P) is favourable in adjuvant treatment of patients with node-positive breast cancer is controversial, as is the benefit of increased density of dosing.
Ardizzoni, Andrea, Barni, Sandro, Bighin, Claudia, Bisagni, Giancarlo, Boni, Corrado, Bruzzi, Paolo, Cavazzini, Giovanna, Cognetti, Francesco, Colantuoni, Giuseppe, De Laurentiis, Michele, De Placido, Sabino, Del Mastro, Lucia, Durando, Antonio, Forestieri, Valeria, Gamucci, Teresa, Garrone, Ornella, Giuliano, Mario, Gravina, Adriano, Montemurro, Filippo, Nisticò, Cecilia, Papaldo, Paola, Puglisi, Fabio, Turletti, Anna, Valle, Enrichetta   +23 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

ارتباط مدت بقای عاری از بیماری و میزان کلی بقا با سن و وجود متاستاز اولیه در بیماران مبتلا به سرطان پستان

مجله دانشکده پزشکی اصفهان, 2013
مقدمه: بر اساس گزارش‌ها، سرطان پستان در کشور ما در حدود یک دهه زودتر از جامعه‌ی جهانی بروز می‌کند. این امر بر اهمیت غربالگری به موقع آن می‌افزاید. انجام غربالگری به افزایش مدت زمان بدون بیماری و طول عمر بیمار کمک می‌کند.
Fariborz Mokarian, Shirin Mokarian, Arash Ramezani   +2 more
doaj