Results 71 to 80 of about 10,142,751 (308)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Disease-Free Survival (DFS) of Patients enrolled in the AHWBI trial by Tumor Subtype

, 2017
Disease-Free Survival (DFS) of Patients enrolled in the AHWBI trial by Tumor ...
Ying Wu (19057), Mark Levine (106449), Robin M. Hallett (328197), Anna Dvorkin-Gheva (201099), John Hassell (3529412), Gregory R. Pond (3611303), Tim Whelan (26979), Kay Dias (3529400), Anita L. Bane (3611300)   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Meta‐Analysis of Recurrence‐Free Survival or Disease‐Free Survival as a Potential Surrogate Endpoint for Overall Survival in Esophageal Cancer Trials

Cancer Reports
Background Cancer trials increasingly use surrogate endpoints, but it is unclear how well recurrence‐free survival (RFS) or disease‐free survival (DFS) specifically predict overall survival (OS) in resectable esophageal cancer (EC).
Uchechukwu Love Anyaduba, Oluwatosin Qawiyy Orababa, Zion Faye, Nazia Rashid, Jason Shafrin, Gregory Reardon   +5 more
doaj   +1 more source

The Role of Complete Blood Count Parameters in Patients with Colorectal Cancer

Acta Clinica Croatica, 2018
Chronic inflammation has been linked with many cancers. It seems that easily available and usual blood inflammatory markers might serve as a prognostic factor for overall survival and disease-free survival in patients with various cancers.
Melih Solak Mekić, Ivo Pedišić, Hrvoje Šobat, Vanja Vučićević Boras, Iva Kirac, Ljilja Štefančić, Mario Šekerija, Borna Vrdoljak, Danko Velimir Vrdoljak   +8 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Prognostic analysis of sleeve lobectomy for non-small cell lung cancer

Zhongguo aizheng zazhi, 2018
Background and purpose: Sleeve lobectomy is considered an acceptable surgery for patients with central lung cancer, and can preserve more lung functions because of the reservation of the normal lung tissues.
郑佳杰, 罗继壮
doaj  

Disease-free survival (DFS) according to OHE status (spayed vs intact), log rank p = 0.026.

, 2019
Disease-free survival (DFS) according to OHE status (spayed vs intact), log rank p = 0.026.
Veronica Kristiansen (4229782), Darko Stefanovski (354118), Amy C. Durham (4229776), Laura Peña (4173), Michael H. Goldschmidt (7548248), Karin U. Sorenmo (7548245), Enrico Radaelli (742528)   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source