Results 101 to 110 of about 1,961,991 (306)

Anatomical Resection Improves Disease-Free Survival After Lung Metastasectomy of Colorectal Cancer

Cancer Management and Research, 2021
Tianyu Liu,1,* Wenju Chang,1,2,* Hao Wang,3,* Qi Lin,1,2,* Ye Wei,1,2 Wentao Tang,1 Yu Liu,1 Yijiao Chen,1 Zhengchuan Niu,1 Yudong Jiang,1 Li Ren,1,2 Jianmin Xu1,2 1Colorectal Cancer Center, Department of General Surgery, Zhongshan ...
Liu T, Chang W, Wang H, Lin Q, Wei Y, Tang W, Liu Y, Chen Y, Niu Z, Jiang Y, Ren L, Xu J   +11 more
doaj  

Long-term disease-free survival of patients with radically resected thymomas: relevance of cell-cycle protein expression [PDF]

, 2005
BACKGROUND. Despite radical Surgical resection, thymomas often recur. The objective of the current retrospective Study was to investigate the prognostic relevance of the expression of cell-cycle proteins in these neoplasms to formulate a possible ...
Ambrogi, V, Baldi, A, Mineo, D, Mineo, T
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Comparison of neoadjuvant cisplatin-based chemotherapy versus radiochemotherapy followed by resection for stage III (N2) NSCLC [PDF]

, 2017
Objective: Comparison of prospectively treated patients with neoadjuvant cisplatin-based chemotherapy vs radiochemotherapy followed by resection for mediastinoscopically proven stage III N2 non-small cell lung cancer with respect to postoperative ...
Guillou, Louis, Krueger, Thorsten, Pezzetta, Edgardo, Ris, Hans-Beat, Stupp, Roger, Taffé, Patrick, von Briel, Christian, Zouhair, Abderrahim   +7 more
core  

Erlotinib in patients with previously irradiated, recurrent brain metastases from non-small cell lung cancer: Two case reports [PDF]

, 2008
Background: With the current improvements in primary lung care, the long-term control of brain metastases becomes a clinical challenge. No established therapeutic approaches exist for cranial relapse after response to previous radiotherapy and systemic ...
Abrey LE, Barbara Poellinger, Ceresoli GR, Delattre Y, Horst Wagner, Hotta K, Joachim von Pawel, Khantia D, Lai CS, Namba Y, Regine WF, Rodrigus P, Thomas Duell, Zabel A   +13 more
core   +1 more source

Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients

OncoTargets and Therapy, 2013
The aim of the study reported here was to assess the disease-free survival and overall survival of patients with endometrial cancer and to determine independent factors affecting the prognosis.This was a retrospective study of a single-center clinical series of 276 patients (mean age 64 years) with histologically confirmed cancer of the corpus uteri ...
Jimenez-Lopez, Jesus, Tejerizo-Garcia,Alvaro, Muñoz-Gonzalez,Jose L., Bartolomé-Sotillos,Sara, Marqueta- Marques,Laura, López-González,Gregorio, Pérez-Regadera Gómez,Jose F.   +6 more
openaire   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Disease-free survival at 2 and 3 years is a significant early surrogate marker predicting the 5-year overall survival in patients treated with radical cystectomy for urothelial carcinoma of the bladder: external evaluation and validation in a cohort of Korean patients

Frontiers in Oncology, 2015
Purpose: We aimed to externally validate the association of 2- and 3-year disease-free survival with 5-year overall survival in patients treated with radical cystectomy for urothelial carcinoma of the bladder.
Hyung Suk eKim, Chang Wook eJeong, Cheol eKwak, Hyeon Hoe eKim, Ja Hyeon eKu   +4 more
doaj   +1 more source

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease ...
Amy Au, Andrew Biankin, Bryan W Miller, Caroline Springer, Christopher Ross Carter, Colin McKay, Colin Steele, David Chang, Emma Shanks, Ewan McGhee, Grazia Saturno, Janine T Erler, Jennifer P Morton, Joshua Leach, Karin Oien, Kurt Anderson, Lynn McGarry, Mark Pinese, Nigel B Jamieson, Owen J Sansom, Paul Timpson, Peter Bailey, Richard Marais, Saadia Karim, Thomas R Jeffry Evans, Timpson P   +25 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source