Results 91 to 100 of about 13,014,863 (297)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Validity and reliability of CDAI in comparison to DAS28 in Iraqi patients with active rheumatoid arthritis

مجلة كلية الطب, 2012
Background: Rheumatoid arthritis (RA) disease activity plays a central role in causing disability both directly and via indirect effects mediated through joint damage.
Faiq I. Gorial
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Estimated cutoff points for the 28-joint disease activity score based on C-reactive protein in a longitudinal register of early arthritis.

, 2010
OBJECTIVE: To estimate the cutoff points for the 28-joint Disease Activity Score (DAS28) calculated using C-reactive protein (CRP) measurements from patients with early arthritis. METHODS: We analyzed data from 568 visits of 207 patients enrolled in our
Castañeda, Santos, Patiño, Esther, Castrejón Fernández, Isabel, Ortiz, Ana M., García Vadillo, Alberto, Toledano Martínez, María Esther, González Álvaro, Isidoro   +6 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

State indicator report on physical activity, 2010 [PDF]

"The State Indicator Report on Physical Activity, 2010, provides information on physical activity behavior and policy and environmental supports within each state.
National Center for Chronic Disease Prevention and Health Promotion (U.S.) Division of Nutrition, Physical Activity and Obesity.
core  

Disease activity assessment for juvenile idiopathic arthritis in transitional care

Reumatismo
Objective. The indices to measure disease activity of chronic arthritis in adulthood and childhood are different. Therefore, assessing the status of the disease in young patients with juvenile idiopathic arthritis (JIA) can be tricky, especially when ...
F. La Torre, C. Coppola, M.G. Anelli, F. Cacciapaglia, G. Lopalco, F. Cardinale, F. Iannone   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A retrospective study of infantile-onset Takayasu arteritis: experience from a tertiary referral center in China

Frontiers in Cardiovascular Medicine
ObjectiveTakayasu artery (TAK) is a chronic inflammatory disease that mainly affects the aorta and its major branches and is rarely reported in infants.
Jing Jin, Yan Zhao, Xiucheng Gao, Panpan Wang, Yingying Liu, Yuting Pan, Zhidan Fan, Haiguo Yu   +7 more
doaj   +1 more source