Results 111 to 120 of about 13,409,216 (289)

A retrospective study of infantile-onset Takayasu arteritis: experience from a tertiary referral center in China

Frontiers in Cardiovascular Medicine
ObjectiveTakayasu artery (TAK) is a chronic inflammatory disease that mainly affects the aorta and its major branches and is rarely reported in infants.
Jing Jin, Yan Zhao, Xiucheng Gao, Panpan Wang, Yingying Liu, Yuting Pan, Zhidan Fan, Haiguo Yu   +7 more
doaj   +1 more source

Calprotectin and lactoferrin faecal levels in patients with Clostridium difficile infection (CDI): a prospective cohort study. [PDF]

, 2014
Measurement of both calprotectin and lactoferrin in faeces has successfully been used to discriminate between functional and inflammatory bowel conditions, but evidence is limited for Clostridium difficile infection (CDI).
Beadsworth, Mike B.J., Swale, Andrew, Mike B J Beadsworth, Munir Pirmohamed (40546), Andrew Swale, Kolamunnage-Dona, Ruwanthi, Chris M Parry, Little, Margaret, Hall, Amanda, Nick J. Beeching (623705), Parry, Chris M, Miyajima, Fabio, Paul Roberts (208537), Roberts, Paul, Fabio Miyajima, Amanda Hall, Ruwanthi Kolamunnage-Dona, Paul Roberts, Mike B. J. Beadsworth (623704), Pirmohamed, Munir, Chris M. Parry (304425), Beeching, Nick J, Munir Pirmohamed, Nick J Beeching, Beeching, Nicholas, Margaret Little (623703), Fabio Miyajima (208536), Andrew Swale (208539), Ruwanthi Kolamunnage-Dona (623706), Margaret Little, Parry, Christopher, Beadsworth, Mike BJ, Amanda Hall (210816)   +32 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rheumatoid Arthritis Disease Activity Index-5: an easy and effective way of monitoring patients with rheumatoid arthritis

Egyptian Rheumatology and Rehabilitation, 2019
Objective To study the utility of the Rheumatoid Arthritis Disease Activity Index-5 (RADAI-5) as a valid tool for daily rheumatoid arthritis (RA) monitoring and to compare its predictability to assess RA activity with respect to Disease Activity Score 28
Vikram S Tanwar, Harpreet Singh, Anjali Saini, Gagandeep Sukhija, Sameer Arora, Ankit Kalra   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Validating 10-joint juvenile arthritis disease activity score cut-offs for disease activity levels in non-systemic juvenile idiopathic arthritis

RMD Open, 2019
Objectives To validate cut-offs of the Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) and to compare them with other patient cohorts.Methods In a national multicentre study, cross-sectional data on recent visits of
Paula Vähäsalo, Paula Keskitalo, Maria Backström, Pirjo Tynjälä, Kristiina Aalto, Minna-Maija Grönlund, Heikki Ylijoki, Anne Putto-Laurila, Johanna Kärki, Sirja Sard, Heini Pohjankoski, Maiju Hietanen, Silke Witter, Helena Lehto, Eliisa Löyttyniemi   +14 more
doaj   +1 more source

The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers [PDF]

, 2006
This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology.
Polman, C.H., Uitdehaag, B.M.J., Eikelenboom, M.J., Petzold, A., Thompson, E.J., Keir, G., Giovannoni, G.   +6 more
core  

Estimated cutoff points for the 28-joint disease activity score based on C-reactive protein in a longitudinal register of early arthritis.

, 2010
OBJECTIVE: To estimate the cutoff points for the 28-joint Disease Activity Score (DAS28) calculated using C-reactive protein (CRP) measurements from patients with early arthritis. METHODS: We analyzed data from 568 visits of 207 patients enrolled in our
Castañeda, Santos, Patiño, Esther, Castrejón Fernández, Isabel, Ortiz, Ana M., García Vadillo, Alberto, Toledano Martínez, María Esther, González Álvaro, Isidoro   +6 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease [PDF]

, 2012
The mitochondria are a vibrant hub for many problems that occur in Alzheimer’s disease. The enzyme amyloid-ß binding alcohol dehydrogenase (ABAD) and Cyclophilin D (CypD) are two key mitochondrial proteins that have essential functions in Alzheimer’s ...
Allen, Zoe Eleanor
core   +2 more sources