Results 111 to 120 of about 13,014,863 (297)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Evaluation of disease activity in pemphigus patients by the autoimmune bullous skin disorder intensity score (ABSIS)

, 2011
Bisher gibt es keinen einheitlichen Bewertungsmaßstab zur Beurteilung der Krankheitsaktivität von Pemphigus-Patienten. Für diese Studie wurde ein neues Score-System entwickelt, der Autoimmune Bullous Skin Disorder Intensity Score (ABSIS), und an ...
Müllers, Anne
core   +1 more source

Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis [PDF]

, 2017
AIM: To investigate of pediatric ulcerative colitis activity index (PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity (Mayo endoscopic score).
Stern, Julia Bender, Lightdale, Jenifer R., Bousvaros, Athos, Rufo, Paul A., Litman, Heather J., Kerur, Basavaraj, Weber, Sarah   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Study on the Correlation between 7-joint Ultrasound Score and Disease Activity in Patients with Rheumatoid Arthritis

Journal of Medical Ultrasound
Background: The objective of this study was to investigate the correlation between the 7-joint ultrasound score (US7) and disease activity in patients with rheumatoid arthritis (RA).
Xiaolong Yu, Qiang Wang, Lin Zhuang, Gaojun Cai, Zun Li, Min Ren, Zihan Jin, Jing Xi   +7 more
doaj   +1 more source

Performance of the Birmingham Vasculitis Activity Score and Disease Extent Index in childhood vasculitides

, 2012
Objectives. To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic ...
Garcia Consuegra, J., Vougiouka, O., Mazur-Zielinska, H., Scarpato, S., Dressler, F., Hasija, R., Barash, J., Ozen, S., Ravelli, A., Pistorio, A., van Rossum, M. A. J., Baskin, E., Galasso, R., Wulffraat, N., Pasic, S., Luqmani, R., Fischbach, M., Calcagno, G., Dolezalova, P., Gonzalez, B., Ruperto, N., Iagaru, N., Demirkaya, E., Apaz, M. T., Martini, A., Hoppenreijs, E., Ioseliani, M.   +26 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Comparison of blood plasma and hemolysate parameters in RA patients sub-grouped according to the disease activity score (DAS).

, 2016
Comparison of blood plasma and hemolysate parameters in RA patients sub-grouped according to the disease activity score (DAS).
Naureen Fatima (2589829), Abdul Qayyum Khan (2589832), Shagufta Moin (2589826), Somaiya Mateen (2589823), Atif Zafar (554849)   +4 more
core   +1 more source