Results 131 to 140 of about 13,014,863 (297)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Measuring disease activity in giant cell arteritis: development and initial validation of a composite disease activity score

Egyptian Rheumatology and Rehabilitation
Objective 1. To develop a scoring system for the GCA Disease Activity 2. To validate the composite of the GCA Disease Activity Score (GCA-DAS). 3. To assess the GCA-DAS feasibility and effectiveness in the routine clinical setting for monitoring and ...
Yasser El Miedany, Maha Elgaafary, Mathias Toth, Deborah Palmer, Sami Bahlas, Safaa Mahran, Mohamed Hassan Abu Zaid, Waleed Hassan, Rahma A. Elziaty, Samar Abd Alhamed Tabra, Walaa Elwakil   +10 more
doaj   +1 more source

Multibiomarker disease activity score: an objective tool for monitoring rheumatoid arthritis? A systematic review and meta-analysis. [PDF]

Rheumatology (Oxford), 2023
Meznerics FA, Kemény LV, Gunther E, Bakó E, Dembrovszky F, Szabó B, Ascsillán A, Lutz E, Csupor D, Hegyi P, Bánvölgyi A, Nagy G.   +11 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Photographic evaluation of clinical activity score in thyroid eye disease.

PLoS ONE
PurposeGiven the subjective nature of clinical activity score (CAS) and variability between observers, this study evaluated the inter-observer variability of soft tissue signs (STS) in the CAS using periocular photographs and compared the diagnostic ...
Gyeong Min Lee, Min Joung Lee, Namju Kim, Hokyung Choung, Hwa Lee, Won-Kyung Cho, Jae Hoon Moon, Sang In Khwarg   +7 more
doaj   +1 more source

Multiple sclerosis disease activity, a multi-biomarker score of disease activity and response to treatment in multiple sclerosis

Frontiers in Immunology
Regular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable tool for measuring disease activity in multiple sclerosis (MS) if they reflect the ...
Alexandru Tatomir, Alexandru Tatomir, Freidrich Anselmo, Dallas Boodhoo, Hegang Chen, Armugam P. Mekala, Vinh Nguyen, Jacob Cuevas, Violeta Rus, Horea Rus, Horea Rus   +10 more
doaj   +1 more source

Feasibility of Conducting Comparative Effectiveness Research and Validation of a Clinical Disease Activity Score for Chronic Nonbacterial Osteomyelitis. [PDF]

J Rheumatol, 2023
Wu EY, Oliver M, Scheck J, Lapidus S, Akca UK, Yasin S, Stern SM, Insalaco A, Pardeo M, Simonini G, Marrani E, Wang X, Huang B, Kovalick LK, Rosenwasser N, Casselman G, Liau A, Shao Y, Yang C, Mosa DM, Tucker L, Girschick H, Laxer RM, Akikusa JD, Hedrich CM, Onel K, Dedeoglu F, Twilt M, Ferguson PJ, Ozen S, Zhao Y.   +30 more
europepmc   +1 more source

Development and Preliminary Validation of a Candidate Disease Activity Score for Gout

, 2013
Disease activity has been operatively defined as presence of urate deposits that lead to acute arthritis and joint damage. Every item of the pool of measures for each core domain recommended by OMERACT for trials in gout was tested for suitability in ...
C. Montecucco, M. A. Cimmino, M. Govoni, M. Manara, M. Matucci Cerinic, G. Minisola, VIROLI, CINZIA, C. A. Scirè, F. Salaffi   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Disease Activity and Related Variables in Patients with Psoriatic Arthritis

The Turkish Journal of Gastroenterology, 2014
Objectives: This study aims to investigate the disease activity and related variables in patients with psoriatic arthritis (PsA). Patients and methods: Fifty patients with PsA, who were diagnosed based on the Classification Criteria for Psoriatic ...
Fatma Gül YURDAKUL, Filiz ESER, Hatice BODUR, Ülker GÜL, Müzeyyen GÖNÜL, Işıl Deniz OĞUZ   +5 more
doaj