Results 141 to 150 of about 13,409,216 (289)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Measuring disease activity in giant cell arteritis: development and initial validation of a composite disease activity score

Egyptian Rheumatology and Rehabilitation
Objective 1. To develop a scoring system for the GCA Disease Activity 2. To validate the composite of the GCA Disease Activity Score (GCA-DAS). 3. To assess the GCA-DAS feasibility and effectiveness in the routine clinical setting for monitoring and ...
Yasser El Miedany, Maha Elgaafary, Mathias Toth, Deborah Palmer, Sami Bahlas, Safaa Mahran, Mohamed Hassan Abu Zaid, Waleed Hassan, Rahma A. Elziaty, Samar Abd Alhamed Tabra, Walaa Elwakil   +10 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Photographic evaluation of clinical activity score in thyroid eye disease.

PLoS ONE
PurposeGiven the subjective nature of clinical activity score (CAS) and variability between observers, this study evaluated the inter-observer variability of soft tissue signs (STS) in the CAS using periocular photographs and compared the diagnostic ...
Gyeong Min Lee, Min Joung Lee, Namju Kim, Hokyung Choung, Hwa Lee, Won-Kyung Cho, Jae Hoon Moon, Sang In Khwarg   +7 more
doaj   +1 more source

Multiple sclerosis disease activity, a multi-biomarker score of disease activity and response to treatment in multiple sclerosis

Frontiers in Immunology
Regular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable tool for measuring disease activity in multiple sclerosis (MS) if they reflect the ...
Alexandru Tatomir, Alexandru Tatomir, Freidrich Anselmo, Dallas Boodhoo, Hegang Chen, Armugam P. Mekala, Vinh Nguyen, Jacob Cuevas, Violeta Rus, Horea Rus, Horea Rus   +10 more
doaj   +1 more source

Ankylosing Spondylitis Disease Activity Score (ASDAS): 2018 update of the nomenclature for disease activity states

Annals of the Rheumatic Diseases, 2018
P. Machado, R. Landewé, D. M. van der Heijde   +2 more
semanticscholar   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Disease Activity and Related Variables in Patients with Psoriatic Arthritis

The Turkish Journal of Gastroenterology, 2014
Objectives: This study aims to investigate the disease activity and related variables in patients with psoriatic arthritis (PsA). Patients and methods: Fifty patients with PsA, who were diagnosed based on the Classification Criteria for Psoriatic ...
Fatma Gül YURDAKUL, Filiz ESER, Hatice BODUR, Ülker GÜL, Müzeyyen GÖNÜL, Işıl Deniz OĞUZ   +5 more
doaj