Results 141 to 150 of about 13,014,863 (297)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of a population-anchored Z-score for MRI-based knee osteoarthritis disease activity: Data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage Open
Objective: We previously developed a novel imaging biomarker, reflecting whole-knee bone marrow lesion and effusion-synovitis volumes, to measure disease activity.
Jonggyu Baek, Julieann C. Patarini, Emily Kirillov, Nhung Vo, Michael J. Richard, Ming Zhang, Kate L. Lapane, Matthew S. Harkey, Grace H. Lo, Shao-Hsien Liu, Charles B. Eaton, Jamie MacKay, Timothy E. McAlindon, Jeffrey B. Driban   +13 more
doaj   +1 more source

Correlation of Hypothyroidism With Disease Activity Score-28 in Patients of Rheumatoid Arthritis. [PDF]

Cureus, 2022
Zohaib A, Rasheed A, Mahmud TE, Hayat U, Shabbir S, Riaz S, Jamil MZZ, Javaid U.   +7 more
europepmc   +1 more source

The Disease Activity Score and the EULAR response criteria.

, 2005
Contains fulltext : 47883.pdf (Publisher’s version ) (Closed access)In rheumatoid arthritis (RA), inflammatory activity cannot be measured using one single variable. For this reason the Disease Activity Score (DAS).
Riel, P.L.C.M. van, Fransen, J.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Influence of Reducing Disease Activity Score on Cervical Spine Deformity in Rheumatoid Arthritis: A Systematic Review. [PDF]

Biomed Res Int, 2022
Veldman AB, Allaart CF, Vleggeert-Lankamp CLA.   +2 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Assessing the dynamic changes in vitiligo: reliability and validity of the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS). [PDF]

J Eur Acad Dermatol Venereol, 2022
van Geel N, Depaepe L, Vandaele V, Mertens L, Van Causenbroeck J, De Schepper S, Van Coile L, Van Reempts A, De Vos AS, Papeleu J, Hoorens I, Mertens D, Wolkerstorfer A, Lommerts JE, Speeckaert R.   +14 more
europepmc   +1 more source

Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis.

, 2016
The continuing morbidity of patients with vasculitis, despite the improved prognosis with aggressive therapy, underlines the need for accurate disease assessment.

core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source