Results 161 to 170 of about 13,014,863 (297)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Associations of cytokines and T cell subsets in chikungunya arthritis participants with arthritis disease activity and the flare score.

Associations of cytokines and T cell subsets in chikungunya arthritis participants with arthritis disease activity and the flare score.
Juan Carlos Perez Hernandez (18189679), Maria Villanueva Colpas (18189676), Estefanie Osorio-Llanes (18189652), Gary L. Simon (7538186), Andres Cadena Bonfanti (6876476), Christopher N. Mores (7419149), Carlos Andres Herrera Gomez (18189622), Samuel Simmens (4449442), Andres Alberto Figueroa Quast (18189682), Gary S. Firestein (13226556), Alfonso Sucerquia Hernández (18189670), Johan Penagos Ruiz (18189691), Evelyn Mendoza-Torres (18189625), Sarah R. Tritsch (18189619), Alberto David Cabana Jimenez (18189643), Wendy Rosales (4842039), Paige Fierbaugh (18189628), Dennys Jimenez (18189649), Geraldine Avendaño (18189634), Jennifer Carolina Martinez Zapata (18189646), Jairo Castellar-Lopez (18189655), Melissa Gregory (18189661), Yerlenis Galvis Crespo (18189640), Karol Suchowiecki (18189658), Paula Bruges Silvera (18189637), Richard L. Amdur (8941865), Joaquin Andres Calderon De Barros (18189685), Ivan Zuluaga (18189664), Leandro Sierra-Carrero (18189673), Liliana Encinales (6540218), Aileen Y. Chang (5316881), José Forero Mejía (18189688), David Boyle (221745), Abigale Proctor (18189667), Carlos Alberto Perez Hernandez (18189631), Karen Martins (3413741)   +35 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Clinical Utility of Change in Nonalcoholic Fatty Liver Disease Activity Score and Change in Fibrosis in NAFLD. [PDF]

Clin Gastroenterol Hepatol, 2021
Tamaki N, Munaganuru N, Jung J, Yonan AQ, Bettencourt R, Ajmera V, Valasek MA, Behling C, Loomba R.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Retraction: A Longitudinal Study of the 28 Joints of Disease Activity Score by Ultrasonographical Examination in Rheumatoid Arthritis Patients. [PDF]

J Med Ultrasound, 2023
europepmc   +1 more source

Dietary Pattern or Weight Loss: Which One Is More Important to Reduce Disease Activity Score in Patients with Rheumatoid Arthritis? A Randomized Feeding Trial. [PDF]

Int J Clin Pract, 2022
Sadeghi A, Tabatabaiee M, Mousavi MA, Mousavi SN, Abdollahi Sabet S, Jalili N.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Development and validation of a composite disease activity score for juvenile idiopathic arthritis

, 2009
Objective. To develop and validate a composite disease activity score for juvenile idiopathic arthritis (JIA), the Juvenile Arthritis Disease Activity Score (JADAS). Methods.
CONSOLARO, ALESSANDRO, VIOLA S, FILOCAMO G, MALATTIA, CLARA, RUPERTO N, BAZSO A, MARTINI, ALBERTO, RAVELLI, ANGELO, PISTORIO A, MAGNI MANZONI S   +9 more
core   +1 more source

Evaluation of the impact of age and adiposity on a multi-biomarker disease activity score before and after adjustment. [PDF]

Clin Rheumatol, 2021
Baker JF, Curtis JR, Chernoff D, Flake DD, Sasso E, Long J, Taratuta E, George MD.   +7 more
europepmc   +1 more source