Results 171 to 180 of about 13,014,863 (297)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis. [PDF]

Arthritis Rheumatol, 2021
Trincianti C, Van Dijkhuizen EHP, Alongi A, Mazzoni M, Swart JF, Nikishina I, Lahdenne P, Rutkowska-Sak L, Avcin T, Quartier P, Panaviene V, Uziel Y, Pruunsild C, Vargova V, Vilaiyuk S, Dolezalova P, Ringold S, Garrone M, Ruperto N, Ravelli A, Consolaro A, Paediatric Rheumatology International Trials Organisation.   +21 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A multi-composite disease activity score (NFKB1-DAS) for NFKB1 insufficiency. [PDF]

J Clin Immunol
Thoma K, Hassunah P, Fliegauf M, Müller G, Caballero Garcia de Oteyza A, Mrovecova P, Kraus H, Agarwal P, Russe MF, Sawitzki B, Petrov L, Vogt K, Camacho Ordonez N, Hirsch A, Geier CB, Krausz M, Goldacker S, Frede N, Ehl S, Salou S, Schulz A, Bakhtiar S, Fasshauer M, Hausmann O, Hüfner AD, Stanulla M, Luijendijk A, Atschekzei F, Sogkas G, Salzer U, Keller B, Proietti M, Warnatz K, Grimbacher B.   +33 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cystatin D as a biomarker for rheumatoid arthritis: relation to disease activity and joint damage

Introduction Rheumatoid arthritis (RA) is a multisystem autoimmune disorder. Autoantibody levels in the serum of RA patients can guide the diagnosis and treatment. Cystatin D is a known inhibitor of cathepsins involved in RA pathogenesis.
Omar M. Mohafez, Sahar A. Elsayed, Ahmed Sedky, Ola Mounir   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inflammation response criteria for rheumatoid arthritis based on the two-component disease activity score. [PDF]

RMD Open
Stadler M, Rivellese F, Plant D, Nair N, Hyrich KL, Isaac J, Morgan A, Wilson AG, Verstappen SMM, Lewis MJ, Bowes J, Pitzalis C, Barton A.   +12 more
europepmc   +1 more source

Development and validation of an alternative ankylosing spondylitis disease activity score when patient global assessment is unavailable. [PDF]

Rheumatology (Oxford), 2021
Ortolan A, Ramiro S, van Gaalen F, Kvien TK, Landewe RBM, Machado PM, Ruyssen-Witrand A, van Tubergen A, Bastiaenen C, van der Heijde D.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source