Results 61 to 70 of about 821,927 (250)

Cross link between monocyte chemotactic protein-1 and rheumatoid arthritis activity and progression

Egyptian Rheumatology and Rehabilitation
Background Rheumatoid arthritis is a chronic, inflammatory, and symmetrical peripheral polyarthritis often associated with extra-articular manifestations, that end in marked functional impairment.
Alaa El-Salawy, Souzan Gado, Hanaa El-Banna   +2 more
doaj   +1 more source

Evaluation of Biological-rhythm Using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN) in Rheumatoid Arthritis

Haseki Tıp Bülteni, 2020
Aim:We aimed to evaluate biological rhythm in rheumatoid arthritis (RA) patients using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN).Methods:Eighty-five RA patients and 85 healthy controls were included in the study ...
Betül Sargın, Gülcan Gürer
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association of Haematological Parameters with Disease Activity Score-28 in Rheumatoid Arthritis

Journal of Evolution of Medical and Dental Sciences
BACKGROUND Rheumatoid arthritis is a chronic autoimmune disorder that causes joint inflammation, pain and stiffness. Early diagnosis and management of RA can prevent deformities and improve quality of life. This study aims to investigate the correlation between haematological parameters (hemoglobin, mean platelet volume, total platelet count, red cell
null Annette Thomas, null Shuba N.
openaire   +1 more source

Quantification and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28

Autoimmunity, 2009
Here we studied and characterized different peripheral blood (PB) regulatory T cell (Treg) subsets in rheumatoid arthritis (RA) patients and tested the hypothesis that changes in these cells can be linked to the degree of inflammation and relapsing/remission periods. PB cells were examined from RA subjects (n = 60) with different disease activity score-
José Miguel, Sempere-Ortells, Vicente, Pérez-García, Gema, Marín-Alberca, Alejandra, Peris-Pertusa, José Miguel, Benito, Francisco Manuel, Marco, José Jacobo, Zubcoff, Francisco Javier, Navarro-Blasco   +7 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Correlation With Disease Activity Score 28 (Das28) With Pulmonary Function Test In Rheumatoid Arthritis Patients

International Journal of Research in Pharmaceutical Sciences, 2020
Rheumatoid Arthritis (RA) is a chronic inflammatory disease of unknown etiology involving both small and large joints with many extra-articular manifestations. There may be a variety of pulmonary complications associated with RA based on its disease activity and levels of RF and anti-CCP titers.
null Rameshwar R, null Srujith C. H., null Jagadeesan M, null Mahendra Kumar, null Prassana Karthik S, null Kannan R, null Magesh Kumar S, null Kavitha M. M.   +7 more
openaire   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

بررسی سطح سرمی ویتامین D و ارتباط آن با شدت بیماری در بیماران آرتریت روماتوئید

مجله دانشکده پزشکی اصفهان, 2017
مقدمه: آرتریت روماتوئید یک بیماری التهابی مزمن پیش‌رونده است که باعث درد و سفتی، تورم و تخریب بافت مفصل می‌شود. این مطالعه، با هدف ارزیابی رابطه‌ی سطح سرمي ويتامين D در افراد مبتلا به آرتريت روماتوئيد با شدت بیماری انجام شد.
Mohsen Noroozi, Mehdi Gholamzadeh-Baeis
doaj  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source