Results 71 to 80 of about 14,610,755 (282)

Prevalence of silent nontraumatic vertebral fracture in rheumatoid arthritis: relation with disease duration, disease activity, corticosteroid, and hip buckling ratio

Egyptian Rheumatology and Rehabilitation, 2014
Objectives To detect the prevalence of silent nontraumatic vertebral fractures (VFs) in patients with rheumatoid arthritis (RA) and its relation with disease duration, disease activity, corticosteroid (CS), and hip buckling ratio (BR).
Mohamed M El-Wakd, Omar H Omar, Hala Abou Senna   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cross link between monocyte chemotactic protein-1 and rheumatoid arthritis activity and progression

Egyptian Rheumatology and Rehabilitation
Background Rheumatoid arthritis is a chronic, inflammatory, and symmetrical peripheral polyarthritis often associated with extra-articular manifestations, that end in marked functional impairment.
Alaa El-Salawy, Souzan Gado, Hanaa El-Banna   +2 more
doaj   +1 more source

Association of Haematological Parameters with Disease Activity Score-28 in Rheumatoid Arthritis

Journal of Evolution of Medical and Dental Sciences
BACKGROUND Rheumatoid arthritis is a chronic autoimmune disorder that causes joint inflammation, pain and stiffness. Early diagnosis and management of RA can prevent deformities and improve quality of life. This study aims to investigate the correlation between haematological parameters (hemoglobin, mean platelet volume, total platelet count, red cell
null Annette Thomas, null Shuba N.
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Depressão, ansiedade e atividade de doença na artrite reumatóide Depression, anxiety and disease activity in rheumatoid arthritis

Revista Brasileira de Reumatologia, 2008
OBJETIVO: Avaliar a prevalência de transtornos psiquiátricos em pacientes com artrite reumatóide (AR), do sexo feminino, e relacionar esses quadros com a atividade de doença.
Antonio Filpi Coimbra da Costa, Marco Antonio Alves Brasil, Jose Angelo Papi, Mario Newton Leitão de Azevedo   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Post Chikungunya Arthritis: A Real Diagnostic and Therapeutic Challenge

Journal of the Dow University of Health Sciences, 2020
Objective: To evaluate the response of disease modifying anti rheumatic drugs (DMARDs) on patients diagnosed with post chikungunya inflammatory arthritis attending outpatient department of Rheumatology, Jinnah Medical College Hospital, Karachi, Pakistan.
Muhammad Ishaq Ghauri, Mohammad Shariq Mukarram, Ashok Kumar, Amir Riaz, Syeda Urooj Riaz, Mohammad Mashood Iqbal   +5 more
doaj   +1 more source

Quantification and phenotype of regulatory T cells in rheumatoid arthritis according to Disease Activity Score-28

Autoimmunity, 2009
Here we studied and characterized different peripheral blood (PB) regulatory T cell (Treg) subsets in rheumatoid arthritis (RA) patients and tested the hypothesis that changes in these cells can be linked to the degree of inflammation and relapsing/remission periods. PB cells were examined from RA subjects (n = 60) with different disease activity score-
José Miguel, Sempere-Ortells, Vicente, Pérez-García, Gema, Marín-Alberca, Alejandra, Peris-Pertusa, José Miguel, Benito, Francisco Manuel, Marco, José Jacobo, Zubcoff, Francisco Javier, Navarro-Blasco   +7 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source