Results 91 to 100 of about 2,559,167 (303)

Operational research in low-income countries: what, why, and how? [PDF]

, 2009
Operational research is increasingly being discussed at institutional meetings, donor forums, and scientific conferences, but limited published information exists on its role from a disease-control and programme perspective.
Anthony D Harries, Balasegaram, Bedelu, Berkley, Chalmers, Costello, Culbert, de Jong, de Radiguès, Guthmann, Hans L Rieder, Harries, Harries, Harries, Harries, Heiden, Kapiriri, Karen Bissell, Katamba, Katikireddi, Kayla Laserson, Lowrance, Mabaera, MacDonald, Micheal Van Herp, Moses Massaquoi, Nobukatsu Ishikawa, O'Brien, Ramos, Reid, Reyburn, Rieder, Rony Zachariah, Scherer, Tony Reid, van Griensven, Walley, Wolffers, Xueref, Zachariah, Zachariah   +40 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Nutritional burden from the global burden of disease

Archives of Medical Science
Material and methodsWe used data from the Global Burden of Disease Study 2019 to calculate the incidence rates of and estimated annual percentage changes (EAPCs) in disability-adjusted life-years (DALYs) due to nutritional deficiencies in 204 countries and territories from 1990 to 2019.ResultsDuring this period, the age-standardized incidence rate of ...
Jian Wang, Lan Chen, Zhu Chen
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Doubling the burden: chronic disease [PDF]

Canadian Medical Association Journal, 2006
Chronic diseases such as cardiovascular disease (CVD), diabetes, obesity, cancer and respiratory diseases cause more than half of the 58 million deaths that occur each year, worldwide.[1][1] ![Figure][2] Figure.
openaire   +2 more sources

Health, Environment and the Burden of Disease: A Guidance Note [PDF]

, 2003
This guidance note examines the conditions which determine whether an environmental hazard is responsible for a substantial amount of disease and whether feasible measures are available to prevent it.

core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The burden of lung disease [PDF]

Thorax, 2006
A timely reminder of the needs of people with respiratory disease in the UK The range of clinical conditions included under the umbrella of “respiratory medicine” is wide. From cancers to obstructive sleep apnoea, interstitial lung disease to airways disease, occupational lung disease to respiratory infections, there is a variety present in ...
openaire   +2 more sources

Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ) [PDF]

, 2018
OBJECTIVE: To develop and validate a new scale to assess treatment burden (the effort of looking after one's health) for patients with multimorbidity. DESIGN: Mixed-methods. SETTING: UK primary care.
Chaplin, Katherine, Duncan, Polly, Gaunt, Daisy, Man, Mei-See, Murphy, Mairead, Salisbury, Chris   +5 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source