Results 111 to 120 of about 6,761,859 (307)

The global epidemiology and health burden of the autism spectrum: findings from the Global Burden of Disease Study 2021 [PDF]

BackgroundHigh-quality estimates of the epidemiology of the autism spectrum and the health needs of autistic people are necessary for service planners and resource allocators.
Erskine, Holly E, Santomauro, Damian F, Mantilla Herrera, Ana M, Newton, Charles RJ   +3 more
core   +1 more source

Nutritional burden from the global burden of disease

Archives of Medical Science
Material and methodsWe used data from the Global Burden of Disease Study 2019 to calculate the incidence rates of and estimated annual percentage changes (EAPCs) in disability-adjusted life-years (DALYs) due to nutritional deficiencies in 204 countries and territories from 1990 to 2019.ResultsDuring this period, the age-standardized incidence rate of ...
Jian Wang, Lan Chen, Zhu Chen
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The burden of skin diseases in China: Global Burden of Disease Study 2019

Archives of Dermatological Research
Abstract Skin diseases continue to affect human health and cause a significant disease burden on the healthcare system.We aimed to report the changing trends in the burden of skin disease in China from 1990–2019, Which has an important role in developing targeted prevention strategies.
Yaoyao, Kong, Peiye, Xing, Pengcheng, Huai, Furen, Zhang   +3 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

High burden of impetigo and scabies in a tropical country. [PDF]

, 2009
BACKGROUND: Impetigo and scabies are endemic diseases in many tropical countries; however the epidemiology of these diseases is poorly understood in many areas, particularly in the Pacific.
Steer Andrew C., Batzloff, Michael R, Jenney Adam W. J., Steer, AC, Kado, Joseph, Batzloff Michael R., Mulholland, EK, Jenney, Adam WJ, Sophie La Vincente, Jonathan R Carapetis, Carapetis, JR, La Vincente, Sophie, La Vincente, S, Waqatakirewa Lepani, Waqatakirewa, L, Mulholland E. Kim, Kado, J, Carapetis, Jonathan R, Batzloff, MR, Carapetis Jonathan R., Lepani Waqatakirewa, Andrew C Steer, Waqatakirewa, Lepani, Mulholland, E Kim, Steer, Andrew C, Joseph Kado, La Vincente Sophie, Jenney, AWJ, Michael R Batzloff, E Kim Mulholland, Adam W J Jenney, Kado Joseph   +31 more
core   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Methods for determining disease burden and calibrating national surveillance data in the United Kingdom: the second study of infectious intestinal disease in the community (IID2 study) [PDF]

, 2010
Background: Infectious intestinal disease (IID), usually presenting as diarrhoea and vomiting, is frequently preventable. Though often mild and self-limiting, its commonness makes IID an important public health problem.
Gray James J, Cowden, JM, Evans, Meirion R, Rodrigues, L.C, Neal, Keith R, Tompkins, David S, O'Brien Sarah J, Gray, JJ, Rodrigues, LC, Neal Keith R, Smith, GE, Hunter, P.R, Hunter, Paul R., Goutam K Adak, Sarah J O'Brien, Hunter, Paul R, Tompkins David S, Tompkins, D.S, Clarence C Tam, Evans, MR, Rait Greta, Gillian E Smith, Rait, G, O'Brien, Sarah J., Bolton, Frederick J, Adak, GK, Adak Goutam K, Hunter, PR, Smith Gillian E, Bolton, Frederick J., Adak, Goutam K., McLauchlin Jim, Letley, L.H, Smith, Gillian E., McLauchlin, J, McLauchlin, Jim, Letley Louise H, Evans Meirion R, Smyth, Brian, Hunter Paul R, Laura C Rodrigues, Jim McLauchlin, Louise H Letley, Letley, LH, Letley, Louise H, Rodrigues, Laura C, Smyth Brian, Rait, Greta, Adak, G.K, Gray, James J, Tam, Clarence C., Cowden, J.M, Neal, K.R, Adak, Goutam K, O'Brien, Sarah J, Keith R Neal, Cowden, John M., Cowden John M, Bolton Frederick J, Paul R Hunter, David S Tompkins, John M Cowden, Evans, Meirion R., Gray, James J., Neal, KR, Greta Rait, Brian Smyth, O'Brien, S.J, Tam Clarence C, Bolton, F.J, Neal, Keith R., Meirion R Evans, Evans, M.R, Tam, Clarence C, O'Brien, SJ, Rodrigues Laura C, Smyth, B, Frederick J Bolton, Smith, Gillian E, Tompkins, David S., Tam, CC, Smith, G.E, Bolton, FJ, James J Gray, Tompkins, DS, Rodrigues, Laura C., Cowden, John M, Gray, J.J, Letley, Louise H., Tam, C.C   +89 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Estimating the Costs and the Disease Burden Associated With Campylobacter Infections and Sequelae in the Netherlands [PDF]

Campylobacter infections pose an important public health problem in the Netherlands. Approximately 79,000 persons per year are estimated to experience symptoms of acute gastroenteritis.
Bernsen, Rob A.J.A.M., Mangen, Marie-Josee J., de Wit, G. Ardine, Havelaar, Arie H., van Koningsveld, Rinske   +4 more
core