Results 131 to 140 of about 1,359,990 (265)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The Green Parkinson's Belt: agricultural regions associated with increased Parkinson's disease burden in Mexico. [PDF]

Front Aging Neurosci
Martinez HR, Luna-Rangel FA, Gonzalez-Bedolla B, Armengol-Garcia C, Rebolledo-Garcia D, Rodriguez BL, Figueroa-Sanchez JA.   +6 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Determinants of gastrointestinal disease burden and survival in systemic AL amyloidosis. [PDF]

Blood Adv
Steinhardt MJ, Muchtar E, Kourelis T, Warsame R, Mauermann ML, Buadi FK, Dingli D, Leung N, Cook J, Go RS, Hayman SR, Gonsalves WI, Kapoor P, Zanwar S, Binder M, Hellou T, Tan M, Halawi H, Fonder A, Hobbs M, Abdallah N, Lin Y, Siddiqui MA, Kyle RA, Kortüm KM, Einsele H, Rajkumar SV, Kumar SK, Gertz MA, Dispenzieri A.   +29 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Disease Burden Attributable to Hip Fractures in Asian Women. [PDF]

Int J Womens Health
Sun W, Dai Z, Lin X, Fang K.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Disease burden in Serbian patients with facioscapulohumeral muscular dystrophy. [PDF]

Front Neurol
Ralic B, Albano N, Viric V, Nuredini A, Azanjac AA, Rajic S, Marjanovic A, Tupler R, Heatwole C, Peric S.   +9 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Global epidemiological trends, distribution of NTDs and malaria, and disease burden projections for the next 15 years. [PDF]

Front Public Health
Huang H, Gao Y, Zhu H, Xu Y, Li M, Meng F, Chen X, Du G, Ma W, Qian J, Li Y, Tan W.   +11 more
europepmc   +1 more source