Results 121 to 130 of about 1,359,990 (265)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Sleep Disorders: A Blind Spot in Disease Burden Research. [PDF]

Int J Public Health
Welter LS, Nissen C, Rasch B, Heinzer R, Datta AN, Piovesana E, Bouvier Gallacchi M, Sterpenich V, Bassetti CLA.   +8 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quantifying the case for prevention: disease burden and cost-effective interventions in UK. [PDF]

J Public Health (Oxf)
Owen L, Taylor M.
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Animal Disease Burden in Nigeria, 2006-2023. [PDF]

Transbound Emerg Dis
Al-Mustapha AI, Adetunji V, Ogundijo OA, Odetokun IA, Oyafajo L, Abali HW, Oyewo M, Abubakar AT, Muhammad SO, Adetunji DA, Odukoya A, Haruna A, Bamidele F, Elelu N, Fasina FO.   +14 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Disease burden associated with influenza activity at the population level. [PDF]

Epidemiol Infect
Miller AC, Boonstra DE, Cavanaugh JE, Boikos C, Hu T, McLaughlin J, Weimken T, Welch V, Polgreen PM.   +8 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cardiovascular disease burden in children with obesity: A narrative review. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Ali SKM, Elnaem BH, Abdullah MA, D'Agostino EM.   +3 more
europepmc   +1 more source