Results 121 to 130 of about 6,761,859 (307)

Injuries associated with housing conditions in Europe : a burden of disease study based on 2004 injury data [PDF]

, 2011
Background The authors recently undertook a study for the World Health Organization estimating the European burden of injuries that can be attributed to remediable structural hazards in the home.
Ormandy, David, Keall Michael D, Baker, Michael G., Michael D Keall, Ormandy David, Baker Michael G, Keall, Michael D., David Ormandy, Michael G Baker   +8 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Burden of inflammatory bowel disease in Belgium, 2020

Inflammatory bowel disease (IBD) comprises digestive disorders resulting from non-infectious inflammation of the colon and gastrointestinal tract. With its global prevalence on the rise, IBD poses significant challenges to healthcare systems.
R. Claerman, B. Devleesschauwer, S. Nayani, R. De Pauw   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Other title: 2010 surveillance report; Other title: Burden of cardiovascular diseases in Connecticut--2010

, 2011
Previously published: The burden of cardiovascular disease in Connecticut : 2006 surveillance report. Hartford : State of Connecticut, Dept. of Public Health, [2006].; "March 2011."; Includes bibliographical references (p.
Poulin, Stephanie M.
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Caregivers Burden: Risk and Related Psychological Factors in Caregivers of Patients with Parkinson’s Disease

, 2022
Introduction Parkinson's disease (PD) is characterized by a progressive loss of autonomy which undoubtedly has a significant impact on the quality of life of caregivers and parents are the main informal caregivers.
Savarese G., Carpinelli L., Pellecchia M. T., Calabrese M .   +3 more
core  

New Methodology for Estimating the Burden of Infectious Diseases in Europe [PDF]

, 2012
Kretzschmar M, Mangen M-JEJ, Pinheiro JP, et al. New Methodology for Estimating the Burden of Infectious Diseases in Europe. PLoS Medicine.
consortium, BCoDE, Fevre, Eric M., Lai Taavi, Claudia Stein, Mangen, MJ, Dep IRAS, FRANCO, ELISABETTA, Fevre, E.M., Kretzschmar, Mirjam, BCoDE consortium, Piotr Kramarz, Havelaar Arie H., Stein Claudia, Mangen, M, Pinheiro, P, Paulo Pinheiro, Beate Jahn, Mangen Marie-Josée J., Havelaar, AH, Cassini, Alessandro, Fèvre Eric M., Havelaar, A, Pinheiro, Paulo, Fevre, Eric, Longhi, Silvia, Havelaar, Arie H, Lai, Taavi, Fèvre, Eric M, Stein, C, Mangen, Marie-Josée J, Longhi, S, Beate Jahn (170765), Mirjam Kretzschmar, Mirjam Kretzschmar (27309), ?, ?, Longhi Silvia, Fèvre, EM, Mangen, M.J.J., Stein, C., Mangen, Marie-Josee E. J., Stein, C,, Cassini Alessandro, Eric M. Fèvre (125784), Pinheiro, Joao Paulo, Mangen, M.J., Pinheiro Paulo, Arie H. Havelaar (170779), Alessandro Cassini (170788), Risk Assessment of Toxic and Immunomodulatory Agents, Taavi Lai, Havelaar, A.H., Kramarz, Piotr, Arie H Havelaar, Kretzschmar Mirjam, Jahn, B., Cassini, A., BCoDE consortium, x, Lai, T, Kramarz, P, Piotr Kramarz (170792), Stein, Claudia, Kramarz Piotr, Jahn, Beate, Fèvre, E, Cassini, A, Marie-Josée J Mangen, Marie-Josée J. Mangen (170760), Havelaar, Arie H., Kretzschmar, M.E.E., Pinheiro, P., Silvia Longhi (170771), Jahn, B, Eric M Fèvre, Ricciardi, Gualtiero, Kretzschmar, M., Paulo Pinheiro (170764), Jahn Beate, Franco, E, Lai, T., Kramarz, P., Alessandro Cassini, Longhi, S., Taavi Lai (170775), Claudia Stein (170785), Silvia Longhi, Kretzschmar, M   +85 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Establishing disease models for the Belgian national burden of disease study: challenges and perspectives

The Belgian national burden of disease study (BeBOD) was launched in 2022, and currently provides disease burden estimates for 38 key diseases. The calculation of the non-fatal component of the disease burden, the Years Lived with Disability (YLD ...
B. Devleesschauwer, R. Claerman, S. Nayani, R. De Pauw   +3 more
core   +1 more source