Results 101 to 110 of about 2,559,167 (303)
Integrated preclinical cardiovascular prevention: a new paradigm to face growing challenges of cardiovascular disease [PDF]
, 2015 Cardiovascular disease (CVD) still represents the leading cause of mortality and morbidity worldwide. Despite considerable improvements in the prognosis of CVD and the significant reduction of CVD mortality obtained during the past half century, patients
Battistoni, Allegra +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Burden of cerebrovascular disease. [PDF]
BMJ, 1970 R M, Acheson, A S, Fairbairn
openaire +6 more sources
Tracking poison ingestion deaths for South Africa: The need for access to timely reliable data
South African Medical JournalThe President of South Africa addressed the nation on 15 November 2024 regarding the rise in food-borne illnesses and related child deaths. In the absence of a clear profile of injury deaths from official cause-of-death data, we used empirical ...
M Prinsloo +6 more
doaj +1 more source
BMC Health Services Research, 2017 Background Information-use is an integral component of a routine health information system and essential to influence policy-making, program actions and research.
Edward Nicol +3 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Our shared burden of diseases [PDF]
Current Biology, 2014 At the end of the year that saw Ebola virus disease dominate the news, experts warn that other zoonoses also pose serious threats. To prepare for disease outbreaks and avoid global epidemics, health services and researchers may have to adopt a broader perspective, known as the 'One Health' paradigm, which links the health of people, domestic and wild ...
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source