Results 101 to 110 of about 4,815,701 (299)

Treatment of HIV/AIDS at South Africa's Largest Employers: Myth and Reality [PDF]

, 1997
Background: In the past three years, many large employers in South Africa have announced publicly their intention of making antiretroviral treatment (ART) available to employees.
Connelly, Patrick, Rosen, Sydney
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Osteoporosis diagnosis and ingredients of prescription medications: a population-based study

Frontiers in Pharmacology
BackgroundOsteoporosis (OP) is common in the elderly, who typically have multiple comorbidities. Current guidelines for managing drug-induced OP are limited due to the complexity of multi-agent medications and the lack of sufficient clinical data ...
Xiaohong Huang, Zhendong Feng, Xiaohua Li, Dongxu Zhu, Dongxu Zhu, Yingze Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Trends and hotspots in pulmonary fibrosis biomarker research: a bibliometric analysis

Frontiers in Medicine
BackgroundPulmonary fibrosis is a fatal disease characterized by progressive scarring of lung tissue, with a complex pathogenesis and limited therapeutic options. The identification of robust biomarkers is critical for addressing key clinical challenges,
Ling Wang, Ling Wang, Jianliang Huang, Jianliang Huang, Gan Tan, Yurou Zhang, Mingkai Xia, Zhen Kang, Yun Xiao, Mingsheng Lei, Mingsheng Lei   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Patient-Assessed Chronic Illness Care (PACIC) scenario in an Indian homeopathic hospital

Journal of Traditional and Complementary Medicine, 2016
Homeopathy research has focused on chronic conditions; however, the extent to which current homeopathic care is compliant with the Chronic Care Model (CCM) has been sparsely shown.
Munmun Koley, Subhranil Saha, Shubhamoy Ghosh, Goutam Nag, Monojit Kundu, Ramkumar Mondal, Rajib Purkait, Supratim Patra, Seikh Swaif Ali   +8 more
doaj   +1 more source

Compartment Model for Controlling Infectious Livestock Disease: Cost-Effective Control Strategies for Johne's Disease In Dairy Herds [PDF]

Replaced with revised version of paper 06/08/11.animal compartment model, dairy cattle disease, Johne’s disease, livestock disease control, Mycobacterium avium subspecies paratuberculosis, Farm Management, Livestock Production/Industries,
Cho, Jaesung, Grohn, Yrjo T., Lu, Zhao, Schukken, Ynte H., Smith, Rebecca L., Tauer, Loren W.   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source