Results 81 to 90 of about 20,357,001 (365)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Corrigendum to “Coronavirus Disease-19: The First 7,755 Cases in the Republic of Korea” [Osong Public Health Res Perspect 2020;11(2):85–90] [PDF]

Osong Public Health and Research Perspectives, 2020
COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention   +1 more
doaj   +1 more source

Does a public single payer system deliver integrated care? A national survey study among professional stakeholders in Denmark

International Journal of Integrated Care, 2008
Background: Integrated health care delivery is a goal of health care systems; to date there has been limited information on the integration of medical care in practice.
Martin Strandberg-Larsen, Allan Krasnik
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Review: management of Parkinson's disease

Neuropsychiatric Disease and Treatment, 2013
David J Pedrosa, Lars Timmermann Department of Neurology, University Hospital Cologne, Cologne, Germany Abstract: Parkinson's disease (PD) is one of the most frequent neurological diseases.
Pedrosa DJ, Timmermann L
doaj  

Recombination and transposition drive genomic structural variation potentially impacting life history traits in a host-generalist fungal plant pathogen

BMC Biology
Background An understanding of plant pathogen evolution is important for sustainable management of crop diseases. Plant pathogen populations must maintain adequate heritable phenotypic variability to survive.
Mark C. Derbyshire, Toby E. Newman, Yuphin Khentry, Pippa J. Michael, Sarita Jane Bennett, Ashmita Rijal Lamichhane, Carolyn Graham-Taylor, Subhash Chander, Claudia Camplone, Simone Vicini, Laura Esquivel-Garcia, Cathy Coutu, Dwayne Hegedus, John Clarkson, Kurt Lindbeck, Lars G. Kamphuis   +15 more
doaj   +1 more source

2021 ESC/EACTS Guidelines for the management of valvular heart disease.

European Heart Journal, 2021
A. Vahanian, F. Beyersdorf, F. Praz, M. Milojevic, S. Baldus, J. Bauersachs, D. Capodanno, L. Conradi, M. de Bonis, R. de Paulis, V. Delgado, N. Freemantle, M. Gilard, K. Haugaa, A. Jeppsson, P. Jüni, L. Pierard, B. Prendergast, J. R. Sádaba, C. Tribouilloy, W. Wojakowski, Franz‐Josef Neumann, Pat A Myers, M. Abdelhamid, S. Achenbach, R. Asteggiano, F. Barili, M. Borger, T. Carrel, J. Collet, Dan Foldager, G. Habib, C. Hassager, A. Irs, B. Iung, M. Jahangiri, H. Katus, Konstantinos C. Koskinas, S. Massberg, Christian Mueller, J. Nielsen, P. Pibarot, A. Rakisheva, M. Roffi, A. Rubboli, E. Shlyakhto, M. Siepe, M. Sitges, L. Sondergaard, M. Sousa‐Uva, G. Tarantini, J. Zamorano   +51 more
semanticscholar   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review [PDF]

, 2009
Exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the natural history of this prevalent and devastating condition. This review provides a concise, state of the art summary on prevention and management of exacerbations.
Hurst, JR, Hurst John R, Wedzicha Jadwiga A, Wedzicha, JA, John R Hurst, Jadwiga A Wedzicha   +5 more
core   +1 more source

Growers’ perceptions and attitudes towards fungicide resistance extension services

Scientific Reports
Agricultural extension services have been successful in promoting knowledge sharing and innovation in agriculture. However, the adoption of new agricultural practices, particularly in integrated pest management, has been slow.
Toto Olita, Michelle Stankovic, Billy Sung, Megan Jones, Mark Gibberd   +4 more
doaj   +1 more source