Results 61 to 70 of about 15,462,776 (238)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Bibliographic Analysis of Scientific Research on Downy Mildew (Pseudoperonospora humuli) in Hop (Humulus lupulus L.)

Agriculture
This study focused on downy mildew in hop caused by the pathogen Pseudoperonospora humuli. A systematic literature review was conducted using bibliometric analysis to explore trends in publishing, prominent research themes, and where research is being ...
Marcia Magalhães de Arruda, Fabiana da Silva Soares, Marcelle Teodoro Lima, Eduardo Lopes Doracenzi, Pedro Bartholo Costa, Duane Nascimento Oliveira, Thayse Karollyne dos Santos Fonsêca, Waldir Cintra de Jesus Junior, Alexandre Rosa dos Santos   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The surgical interval between robot-assisted SEEG and epilepsy resection surgery is an influencing factor of SSI

Antimicrobial Resistance and Infection Control
Background In recent years, the development of robotic neurosurgery has brought many benefits to patients, but there are few studies on the occurrence of surgical site infection (SSI) after robot-assisted stereoelectroencephalography (SEEG).
Xiaolian Xie, Hongwu Yao, Hulin Zhao, Bowei Liu, Yanling Bai, Huan Li, Yunxi Liu, Mingmei Du   +7 more
doaj   +1 more source

Distribution of Plasmopara viticola Causing Downy Mildew in Russian Far East Grapevines

Horticulturae
Downy mildew is a severe disease that leads to significant losses in grape yields worldwide. It is caused by the oomycete Plasmopara viticola. The study of the distribution of this agent and the search for endophytic organisms that inhibit the growth of ...
Nikolay N. Nityagovsky, Alexey A. Ananev, Andrey R. Suprun, Zlata V. Ogneva, Alina A. Dneprovskaya, Alexey P. Tyunin, Alexandra S. Dubrovina, Konstantin V. Kiselev, Nina M. Sanina, Olga A. Aleynova   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Community screening for dementia among older adults in China: a machine learning-based strategy

BMC Public Health
Background Dementia is a leading cause of disability in people older than 65 years worldwide. However, diagnosing dementia in its earliest symptomatic stages remains challenging.
Yan Zhang, Jian Xu, Chi Zhang, Xu Zhang, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yijin Zheng, Zhiguang Zhao   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Osteoporosis diagnosis and ingredients of prescription medications: a population-based study

Frontiers in Pharmacology
BackgroundOsteoporosis (OP) is common in the elderly, who typically have multiple comorbidities. Current guidelines for managing drug-induced OP are limited due to the complexity of multi-agent medications and the lack of sufficient clinical data ...
Xiaohong Huang, Zhendong Feng, Xiaohua Li, Dongxu Zhu, Dongxu Zhu, Yingze Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang   +8 more
doaj   +1 more source