Results 91 to 100 of about 7,831,583 (247)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantifying the mortality and morbidity impact of medicaid work requirements: a modeling studyResearch in context

The Lancet Regional Health. Americas
Summary: Background: Federal Medicaid work requirements, recently enacted under national legislation, are expected to cause substantial disenrollment among low-income adults.
Abhishek Pandey, Yang Ye, Carolyn Bawden, Burton H. Singer, Alison P. Galvani   +4 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Water-related disease outbreaks surveillance /

, 1980
Title from cover.Mode of access: Internet.Vol.
Centers for Disease Control (U.S.), Center for Disease Control.   +1 more
core  

Neuromusculoskeletal modeling in health and disease

This opinion paper provides an overview of musculoskeletal modeling, revealing insights into muscle-tendon kinematics, forces, and joint contact forces during dynamic movements, thereby advancing our understanding of biomechanics.
Falisse, Antoine, Pizzolato, Claudio, Kainz, Hans   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Isatuximab–dexamethasone–pomalidomide combination effects on serum M protein and PFS in myeloma: Development of a joint model using phase I/II data

CPT: Pharmacometrics & Systems Pharmacology
This study aimed at leveraging data from phase I/II clinical trials to build a nonlinear joint model of serum M‐protein kinetics and progression‐free survival (PFS) accounting for the effects of isatuximab (Isa), pomalidomide (Pom), and dexamethasone ...
Antoine Pitoy, Solène Desmée, François Riglet, Hoai‐Thu Thai, Zandra Klippel, Dorothée Semiond, Christine Veyrat‐Follet, Julie Bertrand   +7 more
doaj   +1 more source

Economics of Homeland Security: Carcass Disposal and the Design of Animal Disease Defense [PDF]

In an effort to bolster confidence and protect the nation the U.S. government through agencies like the Department of Homeland Security is identifying vulnerabilities and evolving strategies for protection.
McCarl, Bruce A., Jin, Yanhong H., Haung, Wei   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source