Results 91 to 100 of about 666,620 (307)

Programmable models of growth and mutation of cancer-cell populations

, 2011
In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development.
A.M. Ideta, A.R. Rao, Alberto Policriti, C.J. Mode, D. Gillespie, D. J. Wilkinson, D. Skulj, D.T. Gillespie, Erik de Vink, F. Ciocchetta, F. Ciocchetta, F. Ciocchetta, G. Tanaka, H. Hermanns, Ion Petre, J. R. Norris, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, Luca Bortolussi, M. Ajmone Marsan, M. Bernardo, M. K. Brawer, M.H.A. Davis, P. Lecca, P.A. Abrahamsson, S.K. Jha, T. L. Jackson, T. Mazza   +30 more
core   +2 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Intake of 12 food groups and disability-adjusted life years from coronary heart disease, stroke, type 2 diabetes, and colorectal cancer in 16 European countries

, 2019
Our aim was to estimate and rank 12 food groups according to disability-adjusted life years (DALYs) from coronary heart disease (CHD), stroke, type 2 diabetes (T2D), and colorectal cancer (CRC) in 16 European countries.
Boeing, Heiner, De Henauw, Stefaan, Devleesschauwer, Brecht, Hoffmann, Georg, Iqbal, Khalid, Knüppel, Sven, Michels, Nathalie, Schwedhelm, Carolina, Schwingshackl, Lukas   +8 more
core   +1 more source

Evaluating Modelling Approaches for Medical Image Annotations [PDF]

, 2010
Information system designers face many challenges with regards to selecting appropriate semantic technologies and deciding on a modeling approach for their system.
Bijan Parsia, Jasmin Opitz, Ulrike Sattler   +2 more
core   +5 more sources

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship

eLife, 2020
A key unknown for SARS-CoV-2 is how asymptomatic infections contribute to transmission. We used a transmission model with asymptomatic and presymptomatic states, calibrated to data on disease onset and test frequency from the Diamond Princess cruise ship
Jon C Emery, Timothy W Russell, Yang Liu, Joel Hellewell, Carl AB Pearson, CMMID COVID-19 Working Group, Gwenan M Knight, Rosalind M Eggo, Adam J Kucharski, Sebastian Funk, Stefan Flasche, Rein MGJ Houben   +11 more
doaj   +1 more source

A Bayesian approach to the probability of coronary heart disease subject to the --308 tumor necrosis factor-$\alpha$ SNP

, 2011
We study the correlation of the occurrence of coronary heart disease (CHD) with the presence of the single-nucleotide polymorphism (SNP) at the -308 position of the tumor necrosis factor alpha (TNF-$\alpha$) gene.
Carvalho, C. Sofia, Vourvouhaki, Ekaterini   +1 more
core   +1 more source

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients [PDF]

, 2012
The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival?
Goltsov, Alexey, Khalil, Hilal S., Mitev, Vanio, Scott, Fiona, Sproul, Anne, Tummala, Hemanth, Zhelev, Nikolai   +6 more
core   +3 more sources

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Longitudinal impact of demographic and clinical variables on Health-Related Quality of Life in Cystic Fibrosis [PDF]

, 2015
Objectives: The insights that people with cystic fibrosis have concerning their health are important given that aspects of health-related quality of life (HRQoL) are independent predictors of survival and a decrease in lung function is associated with a ...
A-Rahman, Abbott, Abbott, Abbott, Arrington-Sanders, Bradley, Bradley, Dill, Duff, Feltrim, Fitzmaurice, Gee, Gee, Gee, Goldbeck, Kreft, Kugler, Lowton, Quattrucci, Quittner, Rasbash, Rodgers, Sawicki, Sawicki, Sawicki, Schmitz, Smeritschnig, Spahr, Staab, Taylor, Tierney, Ullrich, Wahl, Walters   +33 more
core   +2 more sources