Results 171 to 180 of about 659,696 (286)

Human Stem Cells in Disease Modelling and Treatment: Bridging the Gap Between Bench and Bedside. [PDF]

Biomedicines
Plaza Reyes A, Calado SM.
europepmc   +1 more source

Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease. [PDF]

Stem Cell Res Ther, 2023
Fear VS, Forbes CA, Shaw NC, Farley KO, Mantegna JL, Htun JP, Syn G, Viola H, Cserne Szappanos H, Hool L, Ward M, Baynam G, Lassmann T.   +12 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Past, present, and future: a situational analysis of infectious disease modelling in Thailand. [PDF]

Lancet Reg Health Southeast Asia
Sittimart M, Rachatan C, Muenkaew P, Dabak SV.   +3 more
europepmc   +1 more source

Comparative analysis of disease modelling for health economic evaluations of systemic therapies in advanced hepatocellular carcinoma. [PDF]

PLoS One, 2023
Zou H, Xue Y, Chen X, Lai Y, Yao D, Ung COL, Hu H.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Enhancing global health security responses through greater inclusion of the global south in infectious disease modelling. [PDF]

BMJ Glob Health
Leung K, Cook AR, Wu JT, McVernon J, Prem K, Jit M, Kingkaew P, Mukhopadhyay S, Isaranuwatchai W, Pan-Ngum W, Teerawattananon Y, Huang A, Djaafara B, Sukmanee J, Phuc TO, Laemlak S, Chua VW, Rattanavipapong W, Dabak SV.   +18 more
europepmc   +1 more source

3D multicellular systems in disease modelling: From organoids to organ-on-chip. [PDF]

Front Cell Dev Biol, 2023
Goldrick C, Guri I, Herrera-Oropeza G, O'Brien-Gore C, Roy E, Wojtynska M, Spagnoli FM.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Organoids: the future of disease modelling and therapeutics. [PDF]

Biomater Transl
Zhou D, Xia Z, Su J.
europepmc   +1 more source