Results 161 to 170 of about 229,289 (316)

Correction: The local burden of disease during the first wave of the COVID-19 epidemic in England: estimation using different data sources from changing surveillance practices

BMC Public Health, 2022
Emily S. Nightingale, Sam Abbott, Timothy W. Russell, CMMID Covid-19 Working Group, Rachel Lowe, Graham F. Medley, Oliver J. Brady   +6 more
doaj   +1 more source

Should infectious disease modelling research be subject to ethics review? [PDF]

Philos Ethics Humanit Med, 2023
Green B.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

New Methods for Integrated Models of Animal Disease Control

Accurate assessments of the epidemiological and economic impacts of an animal disease require the incorporation of feedbacks between disease spread and production incentives. This paper motivates a new modeling framework that is sensitive to the dynamics
Rich, Karl M.
core  

Disease modelling with in vitro vascularised organoids. [PDF]

Dis Model Mech
Kan C, Liu L, Sugimura R.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rebalancing power in infectious disease modelling: Toward inclusive and contextual approaches. [PDF]

PLOS Glob Public Health
Aheto JMK, Auzenbergs M, Ferrari MJ, Portnoy A, Utazi CE, Kakaï RG, Gayawan E, Azam JM, Nonvignon J.   +8 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Perspective: from pathogenesis to treatment in veterinary science through organoid disease modelling. [PDF]

Front Vet Sci
Chen B, Slocombe R, Georgy SR.
europepmc   +1 more source

Editorial: Advances in platforms for disease modelling. [PDF]

Front Cell Dev Biol, 2023
Romorini L, Baweja S, Martin Mateos RM, Mehta G, Jalan-Sakrikar N.   +4 more
europepmc   +1 more source