Results 171 to 180 of about 666,620 (307)

Correction to: The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China

BMC Medicine, 2022
Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez, Richard G. White   +11 more
doaj   +1 more source

The utility of infectious disease modelling in informing decisions for outbreak response: A scoping review. [PDF]

PLOS Glob Public Health
Rao D, Tanveer A, Iftekhar EN, Müller SA, Sherratt K, Röbl K, Carrillo-Bustamante P, Heldt K, Fitzner J, Hanefeld J, Funk S.   +10 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Using modified mRNA for cardiomyocyte proliferation and cardiac genetic disease modelling and treatment. [PDF]

Biochem Soc Trans
Batho CAP, Hudson JE, Wilson CH.
europepmc   +1 more source

Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling. [PDF]

Front Mol Neurosci, 2023
Greener MR, Storr SJ.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Past, present, and future: a situational analysis of infectious disease modelling in Thailand. [PDF]

Lancet Reg Health Southeast Asia
Sittimart M, Rachatan C, Muenkaew P, Dabak SV.   +3 more
europepmc   +1 more source

Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease. [PDF]

Stem Cell Res Ther, 2023
Fear VS, Forbes CA, Shaw NC, Farley KO, Mantegna JL, Htun JP, Syn G, Viola H, Cserne Szappanos H, Hool L, Ward M, Baynam G, Lassmann T.   +12 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Human Stem Cells in Disease Modelling and Treatment: Bridging the Gap Between Bench and Bedside. [PDF]

Biomedicines
Plaza Reyes A, Calado SM.
europepmc   +1 more source