Results 171 to 180 of about 229,289 (316)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modelling the Impact of Compulsory FMD Insurance

This paper compares two ways of financing the combating of Foot and Mouth Disease (FMD) in the EU and uses a simulation model to determine the welfare and production implications of the two systems.
Jansson, Torbjorn, Rabinowicz, Ewa, Norell, Bo   +2 more
core  

Next-Generation In Vitro Pulmonary Platforms for Respiratory Disease Modelling and Therapeutic Development: Current Advances and Future Prospects. [PDF]

Medicina (Kaunas)
Khan F, Verma P, Singh A, Kumar M, Gupta J, Patel GK, Singh S, Kumar V, Yadav AK, Verma V.   +9 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A 3D skeletal muscle system for disease modelling and secretome profiling of Duchenne muscular dystrophy. [PDF]

Skelet Muscle
Zouhair M, Cosentino M, Apa L, Genovese D, Di Iorio SMM, Nicoletti C, Liguoro D, Nanni G, Dinarelli S, Palma A, Boccia C, Forcina L, Sideri S, Mancini R, Ballarino M, Musarò A.   +15 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Disease intelligence and modelling for progressive control of animal trypanosomosis in Africa

Source Agritrop Cirad (https://agritrop.cirad.fr/614579/) * Autres projets (id;sigle;titre): MTF/GLO/1305/BMG;DIMCAT;(ITA) Disease intelligence and modelling for progressive control of animal ...
Barreaux, Antoine, de Gier, Jill, Tildesley, Mike J., Kaye, Alexander, Cecchi, Giuliano, Tennant, Warren, Solano, Philippe, Paone, Massimo, Ngari, Nancy, Onyango, Seth, Halos, Lénaïg, Thevenon, Sophie   +11 more
core   +1 more source

Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling. [PDF]

Brain Commun
Li J, Brown LE, Rambarack N, Chan A, Prakash P, Arber C, Wray S, Ali AB.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Repast Simulation/Modelling System for Geospatial Simulation

, 2007
The use of simulation/modelling systems can simplify the implementation of agent-based models. Repast is one of the few simulation/modelling software systems that supports the integration of geospatial data especially that of vector-based geometries ...
Crooks, AT
core