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FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
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Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling
Ryan M +5 more
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Disease model: Parkinson's disease
Trends in Molecular Medicine, 2003Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions (Lewy bodies) containing alpha-synuclein and ubiquitin.
Shun, Shimohama +3 more
openaire +2 more sources
2022
Mathematical models are essential components of the toolbox of any disease ecologist. They should be used as an integral part of any investigation into the impact and management of infectious disease in wildlife populations. Simple models are important to conceptualize the processes occurring during host–pathogen interactions and to identify key ...
Johannes Foufopoulos +2 more
openaire +1 more source
Mathematical models are essential components of the toolbox of any disease ecologist. They should be used as an integral part of any investigation into the impact and management of infectious disease in wildlife populations. Simple models are important to conceptualize the processes occurring during host–pathogen interactions and to identify key ...
Johannes Foufopoulos +2 more
openaire +1 more source
2018
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
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Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
openaire +2 more sources
2018
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Modeling gastrointestinal anthrax disease
Research in Microbiology, 2023Bacillus anthracis is a spore-forming microbe that persists in soil and causes anthrax disease. The most natural route of infection is ingestion by grazing animals. Gastrointestinal (GI) anthrax also occurs in their monogastric predators, including humans.
Oh, So Young +6 more
openaire +4 more sources
Movement Disorders, 2003
AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
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AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
openaire +2 more sources
Trends in Molecular Medicine, 2001
Mutations in the APC gene are responsible for familial adenomatous polyposis (FAP) and for the majority of sporadic colorectal cancers. The establishment of genotype-phenotype correlations in FAP is often complicated by the great clinical variability observed among carriers of the same APC mutation even within the same kindred.
Fodde, Riccardo, Smits, Ron
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Mutations in the APC gene are responsible for familial adenomatous polyposis (FAP) and for the majority of sporadic colorectal cancers. The establishment of genotype-phenotype correlations in FAP is often complicated by the great clinical variability observed among carriers of the same APC mutation even within the same kindred.
Fodde, Riccardo, Smits, Ron
openaire +1 more source