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How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment. [PDF]
Stem Cell Res TherKalia AK +15 more
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Transcriptomic Analysis of Mineralized Adipose-Derived Stem Cell Tissues for Calcific Valve Disease Modelling. [PDF]
Int J Mol SciBrodeur A +7 more
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Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling
Ryan M +5 more
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Disease model: Parkinson's disease
Trends in Molecular Medicine, 2003Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions (Lewy bodies) containing alpha-synuclein and ubiquitin.
Shun, Shimohama +3 more
openaire +2 more sources
2018
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Osteochondral (OC) lesions are a major cause of chronic musculoskeletal pain and functional disability, which reduces the quality of life of the patients and entails high costs to the society. Currently, there are no effective treatments, so in vitro and in vivo disease models are critically important to obtain knowledge about the causes and to develop
Gema, Jiménez +4 more
openaire +2 more sources
Movement Disorders, 2003
AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
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AbstractParkinson's disease (PD) is a heterogenous disease likely to be caused by more than one specific aetiological factor. In rare familial cases of PD with similar clinical features to the idiopathic form of the disease, the underlying genetic cause has been identified.
Michael, Orth, Sarah J, Tabrizi
openaire +2 more sources
Models of mitochondrial disease
2002Publisher Summary This chapter discusses the molecular mechanisms of disease pathogenesis and describes cell and animal models of respiratory-chain disease. The models that have been developed can be used to address a number of different issues: to demonstrate whether the cause of a given respiratory-chain disease is because of a nuclear or a ...
Danae, Liolitsa, Michael G, Hanna
openaire +2 more sources
2018
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
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Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is known that there are many factors, either genetic or environmental factors, involved in PD, but the mechanism of PD is still not fully understood. Several animal models have been established to study the mechanisms of PD.
Vuu My, Dung, Dang Thi Phuong, Thao
openaire +2 more sources