Results 81 to 90 of about 659,696 (286)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

Molecular Autism, 2020
Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available.
Francesca Cavallo, Flavia Troglio, Giovanni Fagà, Daniele Fancelli, Reinald Shyti, Sebastiano Trattaro, Matteo Zanella, Giuseppe D’Agostino, James M. Hughes, Maria Rosaria Cera, Maurizio Pasi, Michele Gabriele, Maddalena Lazzarin, Marija Mihailovich, Frank Kooy, Alessandro Rosa, Ciro Mercurio, Mario Varasi, Giuseppe Testa   +18 more
doaj   +1 more source

Perspective: A model disease [PDF]

Nature, 2011
Despite its rarity, multiple myeloma is an ideal testing ground for cancer biology, says William Matsui.
openaire   +2 more sources

Intake of 12 food groups and disability-adjusted life years from coronary heart disease, stroke, type 2 diabetes, and colorectal cancer in 16 European countries

, 2019
Our aim was to estimate and rank 12 food groups according to disability-adjusted life years (DALYs) from coronary heart disease (CHD), stroke, type 2 diabetes (T2D), and colorectal cancer (CRC) in 16 European countries.
Boeing, Heiner, De Henauw, Stefaan, Devleesschauwer, Brecht, Hoffmann, Georg, Iqbal, Khalid, Knüppel, Sven, Michels, Nathalie, Schwedhelm, Carolina, Schwingshackl, Lukas   +8 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study. [PDF]

, 2017
IntroductionPopulation-based epidemiological evidence suggests that exposure to ambient air pollutants increases hospitalisations and mortality from chronic obstructive pulmonary disease (COPD), but less is known about the impact of exposure to air ...
Alexis, Neil, Barr, R Graham, Bleecker, Eugene, Bowler, Russell, Breysse, Patrick J, Comellas, Alejandro P, Cooper, Christopher B, Dransfield, Mark, Fan, Vincent S, Gassett, Amanda J, Han, MeiLan K, Hansel, Nadia N, Kaufman, Joel D, Kim, Victor, Krishnan, Jerry A, Martinez, Fernando, Paulin, Laura M, Peng, Roger D, Pirozzi, Cheryl, Woodruff, Prescott G   +19 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Estimating the contribution of different age strata to vaccine serotype pneumococcal transmission in the pre vaccine era: a modelling study

BMC Medicine, 2020
Background Herd protection through interruption of transmission has contributed greatly to the impact of pneumococcal conjugate vaccines (PCVs) and may enable the use of cost-saving reduced dose schedules.
Stefan Flasche, Marc Lipsitch, John Ojal, Amy Pinsent   +3 more
doaj   +1 more source

Not all surveillance data are created equal—A multi‐method dynamic occupancy approach to determine rabies elimination from wildlife [PDF]

, 2019
1. A necessary component of elimination programmes for wildlife disease is effective surveillance. The ability to distinguish between disease freedom and non‐detection can mean the difference between a successful elimination campaign and new epizootics ...
Cliquet F., Gelman A., Glueck T. F., Gruen B., Homer C., MacKenzie D. I., Manning S. E., Mörner T., R Core Team, Ronald G., Rupprecht C.   +10 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source