Results 101 to 110 of about 16,121,002 (311)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A SPATIAL MODEL OF ANIMAL DISEASE CONTROL IN LIVESTOCK: EMPIRICAL ANALYSIS OF FOOT AND MOUTH DISEASE IN THE SOUTHERN CONE [PDF]
This paper presents a multi-market model of animal disease control that extends the current literature by accounting for spatial and inter-temporal relations in both epidemiological and economic variables.
Rich, Karl M., Winter-Nelson, Alex
core
A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson’s disease [PDF]
, 2015 Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding ...
Geldenhuys, Werner +9 more
core +2 more sources
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Translational challenges of animal models in Chagas disease drug development: a review
, 2015 Eric Chatelain,1 Nandini Konar21Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland; 2Merck & Co, Inc, Whitehouse Station, NJ, USAAbstract: Chagas disease, or American trypanosomiasis, caused by Trypanosoma cruzi parasite infection is
Konar N, Chatelain E
core
Animal Models of Diabetic Retinopathy (Part 2) [PDF]
, 2018 Diabetic retinopathy (DR) is one of the leading causes of preventable vision impairment and blindness in the working-age population worldwide. Numerous animal models have been developed for therapeutic drug screening and to further increase our ...
Wong, YHI, Tang, LHC, Lo, ACY
core +1 more source
, 2007 The main purpose of studying animal models of human disease is to gain insight into the underlying mechanisms of the disease. The recognition that chronic obstructive pulmonary disease (COPD) is a global health problem with no effective treatment has ...
LUNGARELLA, GIUSEPPE +3 more
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Inoculum size for experimental animal models for Chagas disease.
, 2015 a trypomastigotes/animalInoculum size for experimental animal models for Chagas disease.
Julián Ernesto Nicolás Gulin (828986) +2 more
core +1 more source
PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
Nature Communications, 2018 Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C.
Jieyu Wu +10 more
doaj +1 more source