Results 81 to 90 of about 1,930,568 (317)

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]

, 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda, Baines, Christopher P, Domeier, Timothy L, Edwards, Jenna C, Emter, Craig A, Ferreira-Nichols, Stephanie C, Ford, David A, Gao, Chen, Ivey, Jan R, Jones, John L, Jurrissen, Thomas J, Klutho, Paula J, Krenz, Maike, McDonald, Kerry S, Olver, T Dylan, Padilla, Jaume, Rau, Christoph, Rector, R Scott, Solaro, R John, Thorne, Pamela K, Veteto, Adam B, Wang, Yibin, Warren, Chad M   +22 more
core  

Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes’ disease [PDF]

, 2016
Legg-Calvé-Perthes' (Perthes') disease is a developmental disease of the hip joint that may result in numerous short and long term problems. The etiology of the disease remains largely unknown, but the mechanism is believed to be vascular and/or ...
Acheson, Acheson, Adler, Allen, Anderson, Arie, Atsumi, Bahmanyar, Barker, Beals, Berg, Bergmann, Bergmann, Bergmann, Bohr, Brown, Bull, Burwell, Burwell, Caffey, Calvé, Camargo, Cameron, Canavese, Cannon, Catterall, Catterall, Choo, Chung, Churchill, Coyle, Crock, Currey, Danforth, Delclaux, Dillman, Donohue, Douglass, Duff, Ebong, Eckerwall, Edvardsen, Eijer, Eijer, Emr, Ezoe, Faraj, Fisher, García Mata, Gaskin, Gautier, Girdany, Goff, Gordon, Gray, Grzegorzewski, Guembecker, Güngör, Hailer, Hall, Hall, Hall, Hall, Hall, Hall, Harrison, Harrison, Harrison, Herndon, Herring, Herring, Hirano, Hofstaetter, Hong, Inoue, Isaac, Iwasaki, Joseph, Joseph, Joseph, Joseph, Kallio, Kamegaya, Kandzierski, Kataoka, Katz, Katz, Kawahara, Kawahara, Kealey, Kealey, Kemp, Kenet, Kim, Kim, Kim, Kim, Kitoh, Koob, Kristmundsdottir, Kristmundsdottir, Kristmundsdottir, Krul, Lappin, Laron, Larson, Lauritzen, Lee, Legg, Ljunggren, Lloyd-Roberts, Loder, Loder, Lubovsky, Madan, Margetts, McQuade, Mickelson, Moberg, Molloy, Moseley, Moulton, Nelitz, O'Higgins, Ogden, Osman, Osorio, Park, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perry, Perthes, Pillai, Pringle, Purry, Rab, Ralston, Rao, Rayfield, Rayner, Reynolds, Richmond, Rowe, Ruff, Salmaso, Salmingo, Salter, Sankar, Sharma, Shore, Smedley, Smith, Stuart, Stulberg, Suehiro, Suehiro, Tanner, Tardieu, Tardieu, Terjesen, Thompson, Thompson, Théron, Tomita, Toogood, Trueta, Tucker, Tutt, Ueo, Upadhyay, Upadhyay, Vasseur, Vaverka, Vila-Verde, Vosmaer, Wang, Weiner, Wiig, Wiig, Wijesekera, Winkleby, Wright, Wynne-Davies, Yoshida, Zarco, Zhang   +191 more
core   +2 more sources

Animal Models for Human Disease

, 2014
This chapter introduces some types of animal models which are used for better understanding the disease mechanisms and its treatment. These experimental models fall into two categories: spontaneous models and induced models. Among the diseases, rheumatoid arthritis (RA) as an autoimmune disease was considered.
Reza Khorramizadeh, M., Saadat, Farshid
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques

Nature Communications
Simian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted envelope virus-like particles, delivered by the DNA/ALVAC platforms, followed by the ΔV1gp120 boost formulated in Alum, protect 50% and 80% of macaques from mucosal ...
Massimiliano Bissa, Mohammad Arif Rahman, Luca Schifanella, Katherine C. Goldfarbmuren, Isabela Silva de Castro, Emmanuel K. Woode, Anna Gutowska, Melvin N. Doster, Sophia Brown, Sarkis Sarkis, Neil R. Kanchetty, Cynthia A. Pise-Masison, Robyn Washington-Parks, Katherine McKinnon, Shraddha Basu, Jiae Kim, Ryan Alving, Dominic Paquin-Proulx, Kombo F. N’guessan, Xiaoying Shen, David C. Montefiori, Timothy Cardozo, Gary R. Matyas, Mangala Rao, Genoveffa Franchini   +24 more
doaj   +1 more source

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

Signal Transduction and Targeted Therapy, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted on mink farms between minks and humans in many countries. However, the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown.
Zhiqi Song, Linlin Bao, Wei Deng, Jiangning Liu, Erjun Ren, Qi Lv, Mingya Liu, Feifei Qi, Ting Chen, Ran Deng, Fengdi Li, Yunpeng Liu, Qiang Wei, Hong Gao, Pin Yu, Yunlin Han, Wenjie Zhao, Junjun Zheng, Xujian Liang, Fuhe Yang, Chuan Qin   +20 more
doaj   +1 more source

Burkholderia pseudomallei: animal models of infection.

, 2008
A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease.
Atkins, Tim, Bancroft, Gregory J, Cuccui, Jon, Easton, Anna, Haque, Ashraful, Harley, Vicki, Russell, Paul, Sarkar-Tyson, Mitali, Titball, Richard W, Wren, Brendan   +9 more
core   +1 more source

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1. [PDF]

, 2018
Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are predisposed to cancer development.
Carlson, Daniel F, Coutts, Alexander W, Dahiya, Sonika, Dombi, Eva, Fahrenkrug, Scott C, Fisher, James, Giovannini, Marco, Gutmann, David H, Isakson, Sara H, Kirstein, Mark N, Largaespada, David A, Messiaen, Ludwine, Moertel, Christopher L, Pluhar, G Elizabeth, Ratner, Nancy, Rizvi, Tilat, Rizzardi, Anthony E, Stemmer-Rachamimov, Anat O, Vitte, Jeremie, Watson, Adrienne L, Widemann, Brigitte C, Williams, Kyle B   +21 more
core   +2 more sources

Animal Models in Behçet's Disease [PDF]

Pathology Research International, 2012
Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis ...
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source