Results 131 to 140 of about 16,121,002 (311)

South Dakota Animal Disease Research & Diagnostic Laboratory User\u27s Guide [PDF]

, 2012
The ADRDL is an accredited AAVLD laboratory and a member of the USDA National Animal Health Network. This document is user\u27s guide for the services provided by the Animal Disease Research and Diagnostic ...
Animal Disease Research and Diagnostic Laboratory, South Dakota State University
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

South Dakota Animal Disease Research & Diagnostic Laboratory: Annual Report 2014 [PDF]

, 2013
This document is the 2014 annual report of the South Dakota Veterinary and Biomedical Science Department Animal Disease Research and Diagnostic ...
Animal Disease Research and Diagnostic Laboratory, South Dakota State University
core  

Shared genetic architecture and causal relationship between sleep behaviors and lifespan

Translational Psychiatry
Poor sleep health is associated with a wide array of increased risk for cardiovascular, metabolic and mental health problems as well as all-cause mortality in observational studies, suggesting potential links between sleep health and lifespan.
Yong Wu, Chu-Yi Zhang, Xiaolan Liu, Lu Wang, Ming Li, Yi Li, Xiao Xiao   +6 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Animal models of systemic sclerosis: their utility and limitations

, 2014
Carol M Artlett Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases ...
Artlett CM
core  

Animal models of Alzheimer’s Disease

, 2017
In the discovery phase of drug development for Alzheimer’s disease it is useful to have animal models in which proof of principle can be obtained. Models of disease symptoms (memory impairment) and models of the disease pathology (lesions, amyloid ...
David Morgan
core   +1 more source