Results 151 to 160 of about 1,153,169 (268)

Prediction of disease resilience of pigs using multi-omics data. [PDF]

J Anim Sci Biotechnol
Chen Y, Lonergan S, Lim KS, Cheng J, Dervishi E, Dyck MK, Steadham E, Canada P, Fortin F, Harding JCS, Plastow GS, Dekkers JCM.   +11 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Animal models for diabetic kidney disease: perspectives and prospects. [PDF]

Front Vet Sci
Zeng M, Gong Q, Shen H, Chen L, Zhang W.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Scoping Review of Machine Learning Applications Across Epidemiological Stages of Zoonotic Disease. [PDF]

Transbound Emerg Dis
Zhang Y, Sun Y, Wang J, Wang L, Fang R, Wu X, Yang X, Guo Y, Li S.   +8 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Corneal Innervation Research at a Crossroads: A Tool-Driven Roadmap for the Future. [PDF]

Invest Ophthalmol Vis Sci
Matynia A, Meng ID, Davis BM, Pflugfelder SC, Galor A, Perez VL, Felix ER, Hamrah P, Rompolas P, Ruiz-Lozano RE, Bhuiyan SA, Moghbeli K, Semizoglou E, Renthal W, Singh H, Das J, Golczak M, Stepp MA, Morgans CW, de Paiva CS, Saab CY, Spigelman I, Sayegh RR, Largent-Milnes TM, Wu H, Luo W, Mitra S, Yoo H, Farsiu S, Littleton S, Jacob E, McPheeters MT, Lapierre-Landry M, Smith JJ, Wang X, Florea R, Widjaja-Adhi MAK, Holmes S, Zemborain Z, Laise KET, Pondelis NJ, Jeong KS, Chen R, Jenkins MW, Lee V, Moulton EA, Jacobs DS, Aicher SA, St Leger AJ, Saban DR.   +49 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Multi-Omics Landscape of Circadian Clock Dysregulation Across the Chronic Liver Disease Spectrum. [PDF]

Int J Mol Sci
Tong S, Chen W, Chen J, Zhu X, Shi A.
europepmc   +1 more source