Results 281 to 290 of about 1,930,568 (317)
Some of the next articles are maybe not open access.
Animal Models of Cardiovascular Disease
Revista Española de Cardiología (English Edition), 2009The use of animal models to study cardiovascular disease has made a substantial contribution to increasing our understanding of disease pathogenesis, has led to the development of diagnostic techniques, and has made it possible to verify the effectiveness of different preventative and therapeutic approaches, whether pharmacological or interventional ...
Francisco J, Chorro +2 more
openaire +2 more sources
Animal models of Wilson disease
2017Wilson disease (WD) is caused by ATPase copper-transporting beta (ATP7B) mutations and results in copper toxicity in liver and brain. Although the defective gene was identified in 1993, the specific mechanisms underlying copper toxicity and the remarkable phenotypic diversity of the disease are still poorly understood.
Valentina, Medici, Dominik, Huster
openaire +2 more sources
Animal Models of Neurodegenerative Diseases
2009Animal models of neurodegenerative disease are excellent tools for studying pathogenesis and therapies including cellular transplantation. In this chapter, we describe different models of Huntington's disease and Parkinson's disease, stereotactic surgery (used in creation of lesion models and transplantation) and finally transplantation studies in ...
Wendy, Phillips +3 more
openaire +2 more sources
Animal Models for Human Diseases
Perspectives in Biology and Medicine, 1982The use of animal models for the study of human disease is for the most part a recent development. This discussion of the use of animal models for human diseases directs attention to the sterile period early advances some personal experiences the human as the model biological oddities among common laboratory animals malignancies in laboratory animals ...
openaire +2 more sources
Animal models for immunodeficiency diseases
Immunology Today, 1992Immunodeficient animals continue to provide insights into the development and function of the immune system. These animals also serve as models for the propagation of normal and malignant human cells and as hosts for infectious agents, including HIV. New developments in basic and applied research using immunodeficient animals were discussed at a recent
Greiner, D L, Rajan, T V, Shultz, L D
openaire +2 more sources
Animal Models for Mitochondrial Disease
2003Mutations in mitochondrial genes encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA have been implicated in a wide range of degenerative diseases. MtDNA base substitution and rearrangement mutations can cause myopathy, cardiomyopathy, ophthalmological defects, growth retardation, movement disorders, dementias, and diabetes.
openaire +2 more sources
Animal Models of Menkes Disease
1999There are three recognized X-linked copper deficiency disorders in humans: classical Menkes disease (MD), mild Menkes disease and occipital horn syndrome (OHS, also known as X-linked cutis laxa). Since the features of these diseases are so distinct, it was not clear until recently whether the phenotypes were due to mutations in the same gene, or ...
J F, Mercer +4 more
openaire +2 more sources
Animal Models of Retinal Disease
2011Diseases of the retina are the leading causes of blindness in the industrialized world. The recognition that animals develop retinal diseases with similar traits to humans has led to not only a dramatic improvement in our understanding of the pathogenesis of retinal disease but also provided a means for testing possible treatment regimes and successful
Erica L, Fletcher +5 more
openaire +2 more sources
Animal Models of Neurological Disease
2010The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology.
Amol, Shah +4 more
openaire +2 more sources