Results 231 to 240 of about 190,151,534 (289)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

The pathogenic role of high-titer anti-Ro52 antibodies in neonatal lupus erythematosus: insights from a 9 case series. [PDF]

Front Pediatr
Cheng S, Jiang Y, Zhang S, Huang J, Wang X, Xie H, Wang M.   +6 more
europepmc   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Arrhythmias in Autoimmune Diseases: Immune-Mediated Mechanisms and Management. [PDF]

J Cardiovasc Dev Dis
Tamirisa KP, Irizarry-Caro JA, Curnutt I, Adusumilli D, Jose M, Jolly M, Torbey E, Volgman AS.   +7 more
europepmc   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

From Ophthalmoplegia to Multilevel Atrioventricular Block: Timing Cardiac Device Therapy in Kearns-Sayre Syndrome. [PDF]

JACC Case Rep
Astavans A, Barth AS.
europepmc   +1 more source

Cardiac arrest revealing an occult interventricular septal hydatid cyst in a child. [PDF]

Trans R Soc Trop Med Hyg
Kulluoglu EP, Durak F.
europepmc   +1 more source

Arrhythmias in Cardiac Sarcoidosis: Pathophysiology, Diagnostic Strategies, Risk Stratification for Sudden Cardiac Death, and Contemporary Management-A Narrative Review. [PDF]

J Clin Med
Guedira M, Nguadi J, Poindron D, Lellouche N, Moini C.   +4 more
europepmc   +1 more source

Unveiling Asymptomatic Atrioventricular Reciprocating Tachycardia in a Patient With Wolff-Parkinson-White Syndrome and Multiple Sclerosis. [PDF]

Am J Case Rep
Gerlt D, Patel R, Mogg M, Bruggemann J, Olafiranye O, Chandrasekaran S.   +5 more
europepmc   +1 more source