Results 251 to 260 of about 190,151,534 (289)

Prevalence, Incidence, and Impact on Mortality of Conduction System Disease in Transthyretin Cardiac Amyloidosis

The American Journal of Cardiology, 2020
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized infiltrative cardiomyopathy in which conduction system disease is common. The aim of our study was to define the incidence and prevalence of high-grade atrioventricular (AV) block requiring pacemaker implantation in our quaternary referral center.
Eoin Donnellan, Oussama M. Wazni, Walid I. Saliba, Mazen Hanna, Mohamed Kanj, Divyang R. Patel, Bryan Wilner, Arshneel Kochar, Wael A. Jaber   +8 more
openaire   +2 more sources

PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy

Current Opinion in Cardiology, 2002
Genetic studies of families with inherited cardiac rhythm disturbances have established a molecular basis for ventricular arrhythmogenic disorders. Genes responsible for the long QT syndrome, Brugada syndrome, and polymorphic ventricular tachycardia have been identified.
Michael H, Gollob, Martin S, Green, Anthony S L, Tang, Robert, Roberts   +3 more
openaire   +2 more sources

Conduction system disease in cardiac amyloidosis

Trends in Cardiovascular Medicine
Cardiac amyloidosis (CA) has diverse and deleterious effects on the conductive system. Atrial fibrillation is by far the most common electrophysiological manifestation of CA and is associated with more mortality, morbidity, and hospitalizations. While AF increases the risk of thrombosis regardless of the CHA2DS2-VASc score, the risk of thromboembolism ...
Ala’ Assaf, Mario Mekhael, Charbel Noujaim, Nour Chouman, Hadi Younes, Omar Kreidieh, Nassir Marrouche, Eoin Donnellan   +7 more
openaire   +2 more sources

Cardiac conduction system disease after transcatheter aortic valve replacement

American Heart Journal, 2012
Transcatheter aortic valve replacement (TAVR) is a rapidly-evolving technology for patients with severe, calcific aortic stenosis. Although these procedures lessen many of the risks and complications of open surgical aortic valve replacement, there remain challenges with TAVR including electrophysiologic complications.
Benjamin A, Steinberg, J Kevin, Harrison, Camille, Frazier-Mills, G Chad, Hughes, Jonathan P, Piccini   +4 more
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Hereditary Long QT Syndrome Associated with Cardiac Conduction System Disease

Pacing and Clinical Electrophysiology, 1989
This report describes the cardiac conduction abnormalities, detected by invasive electrophysiological study, in two identical siblings with symptomatic congenital long QT syndrome. Both patients had evidence of intra‐Hisian conduction delay in response to programmed atrial stimulation and pacing induced infranodal block was seen in one of the two ...
A J, Greenspon, G A, Kidwell, L D, Barrasse, S E, Hessen, M, Giudici   +4 more
openaire   +2 more sources

Abstract P1144: Single-cell RNA-Sequencing Of The Murine Cardiac Conduction System Reveals Transcriptional Regulators Associated With Conduction Development And Disease

Circulation Research, 2023
Rhythmic beating of the heart is driven by a small subset of heart cells, altogether known as the cardiac conduction system (CCS). The CCS consists of unique components including the sinoatrial node (SAN), the atrioventricular node (AVN), the bundle of His, bundle branches and Purkinje fiber (PF) system.
Benjamin Beyersdorf, Felix Atzert, Sean M Wu, William R Goodyer   +3 more
openaire   +1 more source

Cardiac transthyretin amyloidosis in patients with conduction system disease

European Heart Journal
Abstract Background/Introduction Cardiac amyloidosis (CA) is characterized by extracellular deposition of misfolded proteins in the heart. The data suggest that cardiac amyloidosis is underappreciated as a cause of common cardiac diseases or syndromes.
J Pudich, J Plasek, H Pudichova, J Seleng, E Kapsova, J Syler, K Musiolova, D Drienikova, J Pavlicek, J Vaclavik   +9 more
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The cardiac conduction system: History, development, and disease

The heart is the first organ to form during embryonic development, establishing the circulatory infrastructure necessary to sustain life and enable downstream organogenesis. Critical to the heart's function is its ability to initiate and propagate electrical impulses that allow for the coordinated contraction and relaxation of its chambers, and thus ...
Carissa, Lee, Sidra, Xu, Tahmina, Samad, William R, Goodyer, Alireza, Raissadati, Paul, Heinrich, Sean M, Wu   +6 more
openaire   +2 more sources

Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease

American Journal of Physiology-Heart and Circulatory Physiology, 2007
Some mutations of the sodium channel gene NaV1.5 are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current.
Zhu-Shan, Zhang, Joseph, Tranquillo, Valentina, Neplioueva, Nenad, Bursac, Augustus O, Grant   +4 more
openaire   +2 more sources

Electrophysiologic effects of intravenous magnesium in patients with normal conduction systems and no clinical evidence of significant cardiac disease

American Heart Journal, 1988
Parenteral magnesium has been used for several decades in the empiric treatment of various arrhythmias, but the data on its electrophysiologic effects in man are limited. We evaluated the electrophysiologic effects of magnesium sulfate (MgSO4) administration in eight normomagnesemic patients with normal mononuclear cell magnesium content, who had no ...
D L, Kulick, R, Hong, E, Ryzen, R K, Rude, J N, Rubin, U, Elkayam, S H, Rahimtoola, A K, Bhandari   +7 more
openaire   +2 more sources