Results 51 to 60 of about 70,504 (293)

Molecular basis of arrhythmias associated with the cardiac conduction system

, 2014
The cardiac conduction system is responsible for the initiation and coordination of the heartbeat. It consists of three central components: the sinus node, the atrioventricular node, and the His-Purkinje system.
Atkinson, A.J.; id_orcid, Logantha, S.J.R.J., Boyett, M.R., Dobrzynski, H.; id_orcid   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.

, 2014
Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias.
Corfield, VA, Christiansen, M, Corfield, Valerie A, Christiansen, Kasper M, Carlsen, AL, Christiansen, KM, Carlsen, Anting L, Behr, Elijah R, Kanters, JK, Hedley, Paula L, Kanters, Jørgen K., Christiansen, Michael, Behr, ER, Hedley, PL   +13 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Emerging from the Darkness. Sudden Cardiac Death in Cardiac Amyloidosis

Reviews in Cardiovascular Medicine, 2022
Cardiac amyloidosis (CA) manifests as infiltrative cardiomyopathy with a hypertrophic pattern, usually presenting with heart failure with a preserved ejection fraction. In addition, degenerative valvular heart disease, particularly severe aortic stenosis,
Valeria Cammalleri, Valeria Maria De Luca, Giorgio Antonelli, Ombretta Annibali, Annunziata Nusca, Simona Mega, Myriam Carpenito, Danilo Ricciardi, Fiorella Gurrieri, Giuseppe Avvisati, Gian Paolo Ussia, Francesco Grigioni   +11 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Early Disseminated Lyme Disease with Carditis Complicated by Posttreatment Lyme Disease Syndrome

Case Reports in Infectious Diseases, 2017
Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi. When untreated, infection may spread to the heart, nervous system, and joints.
Cheryl Novak, Andrew Harrison, John Aucott   +2 more
doaj   +1 more source

Syncope and paroxysmal atrioventricular block

Journal of Arrhythmia, 2017
Current literature reveals three types of paroxysmal atrioventricular block (AVB) that can cause syncope:Intrinsic paroxysmal atrioventricular block is due to an intrinsic disease of the AV conduction system; this type of “cardiac syncope” is also ...
Milena Aste, Michele Brignole
doaj   +1 more source

Prevalence of Chagas Disease in a U.S. Population of Latin American Immigrants with Conduction Abnormalities on Electrocardiogram. [PDF]

PLoS Neglected Tropical Diseases, 2017
Chagas disease (CD) affects over six million people and is a leading cause of cardiomyopathy in Latin America. Given recent migration trends, there is a large population at risk in the United States (US).
Mahmoud I Traina, Salvador Hernandez, Daniel R Sanchez, Jalal Dufani, Mohsin Salih, Adieb M Abuhamidah, Wilman Olmedo, Jason S Bradfield, Colin J Forsyth, Sheba K Meymandi   +9 more
doaj   +1 more source