Results 31 to 40 of about 5,329,401 (263)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Potential for epidemic take-off from the primary outbreak farm via livestock movements [PDF]

, 2011
Background We consider the potential for infection to spread in a farm population from the primary outbreak farm via livestock movements prior to disease detection.
Mark EJ Woolhouse, Tildesley, Michael J., Volkova Victoriya V, Victoriya V Volkova, Woolhouse, M. E. J. (Mark E. J.), Tildesley Michael J, Woolhouse Mark EJ, Volkova, Victoriya V., Volkova, Victoriya, Michael J Tildesley, Woolhouse, Mark E. J.; id_orcid   +10 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

RANK-BASED TEMPO-SPATIAL CLUSTERING: A FRAMEWORK FOR RAPID OUTBREAK DETECTION USING SINGLE OR MULTIPLE DATA STREAMS [PDF]

, 2012
In the recent decades, algorithms for disease outbreak detection have become one of the main interests of public health practitioners to identify and localize an outbreak as early as possible in order to warrant further public health response before a ...
Que, Jialan
core  

Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: expansion of ST217 hypervirulent clonal complex in West Africa. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae serotype 1 causes > 20% of invasive disease, among all age groups combined, in The Gambia. In contrast, it is rarely detected in carriage studies. This study compares the molecular epidemiology of S.
Greenwood, Brian M, Martin Antonio, Uzochukwu Egere, Egere Uzochukwu, Akisanya, Abiodun, Sankareh Kawsu, George Lahai, Kawsu Sankareh, Timothy Awine, Nsekpong, David, Lahai George, Hakeem Ishrat, Zaman, Syed MA, Hill Philip C, Syed MA Zaman, Awine, Timothy, Egere, Uzochukwu, Secka, Ousman, Sankareh, Kawsu, Awine Timothy, Richard A Adegbola, Godwin Enwere, Ousman Secka, Philip C Hill, Felicity Cutts, Akisanya Abiodun, Nsekpong David, Lahai, George, Cutts Felicity, Secka Ousman, Hakeem, Ishrat, Cutts, Felicity, Antonio Martin, Enwere Godwin, Tumani Corrah, Corrah, Tumani, Adegbola Richard A, Hill, Philip C, Brian M Greenwood, Adegbola, Richard A, David Nsekpong, Corrah Tumani, Enwere, Godwin, Zaman Syed MA, Greenwood Brian M, Antonio, Martin, Ishrat Hakeem, Abiodun Akisanya   +47 more
core   +1 more source

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

epicontacts: Handling, visualisation and analysis of epidemiological contacts [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research, 2018
Epidemiological outbreak data is often captured in line list and contact format to facilitate contact tracing for outbreak control. epicontacts is an R package that provides a unique data structure for combining these data into a single object in order ...
VP Nagraj, Nistara Randhawa, Finlay Campbell, Thomas Crellen, Bertrand Sudre, Thibaut Jombart   +5 more
doaj   +1 more source

The Coronavirus Disease 2019 Outbreak Highlights the Importance of Sex-sensitive Medicine

European Cardiology Review, 2020
The novel coronavirus disease 2019 (COVID-19) pandemic has revealed important differences between the sexes in epidemiology, risk factors, clinical course, mortality and socioeconomic dimensions of the disease in all populations worldwide.
Angela HEM Maas, Sabine Oertelt-Prigione
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Population sensitivity of acute flaccid paralysis and environmental surveillance for serotype 1 poliovirus in Pakistan: an observational study

BMC Infectious Diseases, 2018
Background To support poliomyelitis eradication in Pakistan, environmental surveillance (ES) of wastewater has been expanded alongside surveillance for acute flaccid paralysis (AFP).
Kathleen M. O’Reilly, Robert Verity, Elias Durry, Humayun Asghar, Salmaan Sharif, Sohail Z. Zaidi, M. Zubair M. Wadood, Ousmane M. Diop, Hiro Okayasu, Rana M. Safdar, Nicholas C. Grassly   +10 more
doaj   +1 more source