Results 41 to 50 of about 5,329,401 (263)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations

Scientific Reports, 2017
Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown.
Anais Bompard, Dari F. Da, Rakiswendé S. Yerbanga, Sumi Biswas, Melissa Kapulu, Teun Bousema, Thierry Lefèvre, Anna Cohuet, Thomas S. Churcher   +8 more
doaj   +1 more source

Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum (s.l.): implications for vector control as a complementary strategy for onchocerciasis elimination in Africa

Parasites & Vectors, 2018
Background In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that elimination may not be achieved with
Isobel Routledge, Martin Walker, Robert A. Cheke, Samir Bhatt, Pierre Baleguel Nkot, Graham A. Matthews, Didier Baleguel, Hans M. Dobson, Terry L. Wiles, Maria-Gloria Basañez   +9 more
doaj   +1 more source

Update: Outbreak of legionnaires’ disease in Norway traced to air scrubber

, 2005
As of 8 June 2005, 55 cases of legionnaires’ disease including ten deaths have been diagnosed associated with an outbreak in southeast ...
K Nygård, Collective Outbreak investigation collaborators   +1 more
core   +1 more source

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. [PDF]

, 2010
The unparalleled collection of clinical data and biomaterials within the EHDN's REGISTRY can expedite the search for disease modifiers (genetic and environmental) of age at onset and disease progression that could be harnessed for the development of ...
Handley, Olivia J, Landwehrmeyer, G Bernhard, Aileen K Ho, Bisson, Jonathan Ian, Schwenke C, David Craufurd, Dunnett, Stephen B., Handley, Olivia, Investigators of the European Huntington's Disease Network, The, DI MARIA, EMILIO, Craufurd D, Dunnett, SB, Carsten Schwenke, the investigators of the European Huntington's Disease Network, Craufurd, David, Edward Wild, Landwehrmeyer, GB, Busse, Monica, Rosser, Anne Elizabeth, Olivia J Handley, Romano Silvia., Tabrizi SJ, Ho, Aileen K., Wild, E, Landwehrmeyer GB, Craufurd, D, Tabrizi, SJ, Tabrizi, Sarah J., Handley, OJ, Rickards, Hugh, Dunnett, Stephen, Ho, Aileen K, Orth, Michael, Ho, AK, Wild, Edward, Stephen B. Dunnett, Sarah J Tabrizi, Wild, EJ, Landwehrmeyer, G. Bernhard, Naji, Jenny, Landwehrmeyer, G. Bernhard, Wild E, Investigators of the European Huntington's Disease Network, Handley, Olivia J., Orth, M, Ellison-Rose, Lynda, Tabrizi, Sarah J, Price, Kathleen, Ho AK, ABBRUZZESE, GIOVANNI, Schwenke, C, Ho, A, Orth M, Handley OJ, Schwenke, Carsten, Dunnett SB, Dunnett, Stephen B, Michael Orth, G. Bernhard Landwehrmeyer   +59 more
core   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Factors Contributing to Urban Malaria Transmission in Sub-Saharan Africa: A Systematic Review

Journal of Tropical Medicine, 2012
Sub-Saharan Africa suffers by far the greatest malaria burden worldwide and is currently undergoing a profound demographic change, with a growing proportion of its population moving to urban areas.
Prathiba M. De Silva, John M. Marshall
doaj   +1 more source

Two epidemiologic patterns of norovirus outbreaks: surveillance in England and wales, 1992-2000. [PDF]

, 2003
In the period 1992-2000, the Public Health Laboratory Service Communicable Disease Surveillance Centre collected standardized epidemiologic data on 1,877 general outbreaks of Norovirus (formerly "Norwalk-like virus") infection in England and Wales ...
Reacher, Mark H, Goutam K Adak, Mark Reacher, Lopman, Benjamin A, Ben Lopman, David W.G. Brown, Brown, David WG, Adak, Goutam K   +7 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Investigation of a Q fever outbreak in a Scottish co-located slaughterhouse and cutting plant [PDF]

, 2010
Outbreaks of Q fever are rare in the UK. In 2006, the largest outbreak of Q fever in Scotland occurred at a co-located slaughterhouse and cutting plant with 110 cases.
Pollock, K.G.J., Wilson, L.E., Donaghy, M., Browning, L.M., Stewart, W.C., Young, D., Prempeh, H., Couper, S.   +7 more
core   +4 more sources