Results 91 to 100 of about 12,789,497 (387)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

Journal of Neuroscience, 2017
Neuroinflammation is an important contributor to Alzheimer's disease (AD) pathogenesis, as underscored by the recent identification of immune-related genetic risk factors for AD, including coding variants in the gene TREM2 (triggering receptor expressed ...
T. Jay, Anna Hirsch, Margaret L Broihier, Crystal M Miller, L. Neilson, R. Ransohoff, B. Lamb, G. Landreth   +7 more
semanticscholar   +1 more source

Effects of Allopurinol on the Progression of Chronic Kidney Disease.

New England Journal of Medicine, 2020
BACKGROUND Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular filtration rate (eGFR) in patients with chronic ...
S. Badve, E. Pascoe, A. Tiku, N. Boudville, F. Brown, A. Cass, Philip Clarke, N. Dalbeth, R. Day, Janak R de Zoysa, B. Douglas, R. Faull, D. Harris, C. Hawley, Graham R D Jones, J. Kanellis, S. Palmer, V. Perkovic, G. Rangan, DM Reidlinger, Laura Robison, R. Walker, G. Walters, David W. Johnson   +23 more
semanticscholar   +1 more source

An Evaluation of a Battery of Functional and Structural Tests as Predictors of Likely Risk of Progression of Age-Related Macular Degeneration. [PDF]

, 2018
Purpose: To evaluate the ability of visual function and structural tests to identify the likely risk of progression from early/intermediate to advanced AMD, using the Age-Related Eye Disease Study (AREDS) simplified scale as a surrogate for risk of ...
Bailey, C., Binns, A. M., Margrain, T. H., Robinson, D. G.   +3 more
core   +3 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

The pattern of pro- and anti-inflammatory cytokine secretion in patients with secondary edematous breast cancer

Zaporožskij Medicinskij Žurnal, 2021
Secondary edematous breast cancer (SEBC), T4b, has a poor prognosis. The aim of this study is to examine the balance in serum levels of pro-inflammatory (TNFά, IL-8) and anti-inflammatory (IL-4) cytokines in patients with SEBC before special treatment.
O. M. Bilyi, N. A. Mitriaieva, M. V. Krasnoselskyi, L. V. Hrebinyk   +3 more
doaj   +1 more source

Rapidly Progressive Alzheimer Disease [PDF]

Archives of Neurology, 2011
Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs.
Martin Wolff, Inga Zerr, Christian Schmidt, Carsten Korth, Michael Weitz, Thomas Bartlau   +5 more
openaire   +4 more sources

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy [PDF]

, 2013
BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing ...
Gillingwater, T. H., Hunter, G., Lamont, D. J., Mutsaers, C. A., Wishart, T. M.   +4 more
core   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Targeting the Progression of Parkinsons Disease [PDF]

Current Neuropharmacology, 2009
By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion (50-70%) of the cells in the substantia nigra (SN) has already been destroyed. This degeneration progresses until, within a few years, most of the cells have died.
George, JL, Mok, S, Moses, D, Wilkins, S, Bush, AI, Cherny, RA, Finkelstein, DI   +6 more
openaire   +4 more sources