Results 91 to 100 of about 7,373,821 (305)

Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response

The Journal of Pathology: Clinical Research, 2020
Lymphangioleiomyomatosis (LAM) is a rare multisystem disease with a variable clinical course. The lungs are infiltrated by nodules of LAM cells, stromal cells and inflammatory cells, causing lung cysts and respiratory failure. We used immunohistochemical
Suzanne Miller, Iain D Stewart, Debbie Clements, Irshad Soomro, Roya Babaei‐Jadidi, Simon R Johnson   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Predict Disease Progression With Reaction Rate Equation Modeling of Multimodal MRI and PET

Frontiers in Aging Neuroscience, 2018
Neurodegenerative dementia often has multiple types of underlying pathology, for example, beta-amyloid, misfolded tau, chronic neuroinflammation and neurodegeneration may coexist in Alzheimer’s disease.
Li Su, Li Su, Yujing Huang, Yi Wang, James Rowe, John O’Brien   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fluidity of HIV-1-specific T-cell responses during acute and early subtype C HIV-1 infection and associations with early disease progression. [PDF]

, 2010
Deciphering immune events during early stages of human immunodeficiency virus type 1 (HIV-1) infection is critical for understanding the course of disease.
Gray, Clive M, van Loggerenberg, Francois, Mlotshwa, Mandla., Loggerenberg, Francois van, Treurnicht, Florette K., Mlisana, Koleka Patience., Catherine Riou, Chopera, Denis, Mandla Mlotshwa, Denis Chopera, Gray, Clive M., Woodman, Zenda., CAPRISA 002 Study Team, Salim Abdool Karim, Mlisana, Koleka, Riou, Catherine, Abdool Karim, Salim Safurdeen., Ntale, Roman, Ntale, Roman., Williamson, Carolyn., Carolyn Williamson, Francois van Loggerenberg, Werner, Lise., Treunicht, Florette, Chopera, Denis Rutendo., Mlisana, Koleka P., Roman Ntale, de Assis Rosa, Debra, Debra de Assis Rosa, Woodman, Zenda, Zenda Woodman, Florette Treunicht, Williamson, Carolyn, Lise Werner, de Assis Rosa, Debra., Werner, Lise, Abdool Karim, Salim, Riou, Catherine., van Loggerenberg, Francois., Mlotshwa, Mandla, Koleka Mlisana, Chopera, Denis R., Assis Rosa, Debra de, Clive M. Gray   +43 more
core   +1 more source

Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease.

, 2023
BackgroundAlzheimer's disease (AD) is a common neurodegenerative disease and mild cognitive impairment (MCI) is considered as the prodromal stage of AD.
Lutz, Michael W, Li, Huiyue, Liu, Hongliang, Luo, Sheng, Alzheimer’s Disease Neuroimaging Initiative   +4 more
core   +1 more source

Insights into Disease Progression of Translational Preclinical Rat Model of Interstitial Pulmonary Fibrosis through Endpoint Analysis

Cells
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease characterized by the relentless deposition of extracellular matrix (ECM), causing lung distortions and dysfunction.
Anil H. Kadam, Jan E. Schnitzer
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source