Results 231 to 240 of about 7,373,821 (305)

Deletion of the T1D risk gene <i>Ormdl3</i> in β-cells does not impact disease progression. [PDF]

Biochem Biophys Rep
Ou Q, Jones EF, Currey K, Engin F.
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Normalizing flow based neural processes for Alzheimer's disease progression prediction. [PDF]

PLoS One
Al-Anbari E, Karshenas H, Shoushtarian B.   +2 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

CCL5 Levels, Disease Progression, and Mortality in Respiratory Viral Infections: A Systematic Review and Meta-Analysis.

JAMA Netw Open
Pita-Martínez C, Sepúlveda-Crespo D, Bermejo-Martín JF, Martínez I, Resino S.   +4 more
europepmc   +1 more source

Toolkit for multistate disease progression simulation and treatment decision-making aid. [PDF]

BMC Med Res Methodol
Xie C, Li R, Saber W, Cortes JE, Short NJ, Huang X.   +5 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy. [PDF]

JACC Basic Transl Sci
Penna VR, Amrute JM, Engel M, Shiel EA, Farra W, Cannon EN, Leu-Turner C, Ma P, Villanueva A, Shin H, Parvathaneni A, Jager J, Bueno-Beti C, Asimaki A, Lavine KJ, Saffitz JE, Chelko SP.   +16 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Integrative multi-omics analysis reveals lipid/metabolite dysregulation and temporal decoupling in disease progression. [PDF]

Sci Rep
Anyaegbunam UA, Ten Cate V, Bauer K, Schmidlin T, Distler U, Tenzer S, Araldi E, Bindila L, Wild P, Andrade-Navarro MA.   +9 more
europepmc   +1 more source