Results 241 to 250 of about 7,373,821 (305)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Robust transcriptomic signatures of Alzheimer's disease progression: validated explainable AI approach. [PDF]

Sci Rep
Shafik RA, Afify YM, Badr N, Mounir M.
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Association of Valvular Disease Progression Using Echocardiographic Findings in a Large U.S. Cohort. [PDF]

Echocardiography
Bautista Neughebauer AA, Yehya A, Benza RL, Talreja D.   +3 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru. [PDF]

Emerg Infect Dis
Wang R, Huang CC, Becerra MC, Calderon RI, Contreras CC, Galea JT, Jimenez J, Lecca L, Yataco RM, Zhang Z, Murray MB.   +10 more
europepmc   +1 more source

Functional disease progression in children with inherited peripheral neuropathies: A prospective cohort study. [PDF]

J Neuromuscul Dis
Vill K, Tacke M, König A, Senderek J, Hannibal I, Walter MC, Schlotter-Weigel B, Thiele S, Wagner J, Netzer M, Müller-Felber W, Hobbiebrunken E, Blaschek A.   +12 more
europepmc   +1 more source

Foamy microglia link oxylipins to disease progression in multiple sclerosis. [PDF]

Nat Neurosci
van der Vliet D, Di X, Shamorkina TM, Coulon-Bainier C, Pavlovic A, van der Vliet IACM, Zeng Y, Macnair W, van Egmond N, Chen JQA, van den Bosch AMR, Engelenburg HJ, Wever D, Mason MRJ, Driever WPF, Gagestein B, Dusseldorp E, van Eijk M, Grether U, Netherlands Brain Bank, Harms AC, Hankemeier T, Collin L, Heck AJR, Huitinga I, van der Stelt M.   +25 more
europepmc   +1 more source

Purinergic activity of circulating extracellular vesicles associates with disease progression in melanoma. [PDF]

Oncoimmunology
Najjar YG, Hong CS, Menshikova EV, Kirkwood JM, Diergaarde B, Jackson EK, Whiteside TL.   +6 more
europepmc   +1 more source

Simulation of long-term lecanemab treatment effect on Alzheimer's disease progression. [PDF]

Alzheimers Dement (N Y)
Williams T, Jang SR, Lanctôt KL, Kang A, Bloudek L, Wang G.   +5 more
europepmc   +1 more source