Results 271 to 280 of about 13,239,682 (316)

Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression.

Journal of genetics and genomics = Yi chuan xue bao, 2019
Mass spectrometry (MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic phenotypes. The metabolomes of cells, tissues, and organisms comprise a variety of
Raoxu Wang, Bowen Li, S. Lam, G. Shui
semanticscholar   +1 more source

Progression in Parkinson's Disease

Cold Spring Harbor Perspectives in Medicine
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by relentlessly progressive motor and nonmotor clinical features. In this paper, we offer a comprehensive overview of progression in PD, covering the heterogeneous symptomatology crucial for monitoring progression from clinical, pathological, and biomarker perspectives.
Krithi, Irmady, Serge, Przedborski
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Progressive Shrinkage of Involved Arteries in Parallel with Disease Progression in Moyamoya Disease

World Neurosurgery, 2019
Recent three-dimensional constructive interference in steady state (3D-CISS) studies have shown that the involved arteries decrease not only their own luminal caliber but also outer diameter in moyamoya disease (MMD). This study was aimed to clarify how the outer diameter of the involved arteries serially change during disease progression in MMD using ...
Shusuke Yamamoto, Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda   +5 more
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Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

Alzheimer's & Dementia, 2018
The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite, longitudinal, observational study that has collected many biomarkers since 2004 ...
D. Veitch, Michael W Weiner, P. Aisen, L. Beckett, N. Cairns, R. C. Green, D. Harvey, C. Jack, W. Jagust, J. Morris, Ronald C. Petersen, A. Saykin, Leslie M. Shaw, Arthur W. Toga, J. Trojanowski   +14 more
semanticscholar   +1 more source

Rate of Progression of Alzheimer's Disease

Journal of the American Geriatrics Society, 1989
We determined rate of cognitive decline in 54 patients with a clinical diagnosis of Alzheimer's disease. Cognitive ability was assessed by score on the Blessed test of orientation, memory, and concentration. Rate of progression was defined as the change in score on the Blessed test per year and was computed using a linear regression analysis.
E, Ortof, H A, Crystal
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The progression of Parkinson disease

Neurology, 2007
Recent neuropathologic studies suggest that Parkinson disease (PD) does not begin in the substantia nigra compacta (SNc) but only involves this region later in the course of the disease. It is proposed that once the SNc is affected by the original pathobiological process (for example, protein aggregation), additional processes more specific to ...
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Progressive patterns in breast diseases

Medical Hypotheses, 1980
Abstract The progressive increase of cyclic nucleotide values from normal breast tissue to benign disease to cancer suggests a natural progression of breast diseases. A promotional role for caffeine and other methylxanthines on fibrocystic breast disease in predisposed women, which has been established, coupled with epidemiological studies which ...
M K, Foecking, J P, Minton, R H, Matthews   +2 more
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Progress in Infectious Disease and Immunology

JAMA, 2011
INFECTIOUS DISEASES ARE COMMONLY ENCOUNTERED IN VIRtually all areas of health care, can represent potential major threats to communities and public health, and account for substantial morbidity and mortality. On a global level, infectious diseases such as malaria and tuberculosis remain leading causes of death.
Gianna, Zuccotti, Phil B, Fontanarosa
openaire   +2 more sources

Biomarkers for the progression of Parkinson disease

Neurology, 2016
The chief outlay for a study of the progression of Parkinson disease (PD) is time, and many of the important scientific returns from the Parkinson's Progression Markers Initiative database lie in the future. Pagano et al.1 have conducted a cross-sectional survey of the de novo PD patient cohort.
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Markers for Progression of Coronary Disease

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2001
Endothelial cells play numerous physiologic roles including regulation of vascular tone, regulation of hemostasis and fibrinolysis, regulation of inflammatory processes, and maintenance of a permeability barrier to provide for exchange and active transport of substances into the artery wall.
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