Results 291 to 300 of about 11,389,344 (365)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Evaluating the kidney disease progression using a comprehensive patient profiling algorithm: A hybrid clustering approach. [PDF]

PLoS One
Al-Mamun MA, Jeun KJ, Brothers T, Asare EO, Shawwa K, Ahmed I.   +5 more
europepmc   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Hippocampal CA1 neuron, a crucial regulator for chronic stress exacerbating Alzheimer's disease progression. [PDF]

Cell Biosci
Gao QL, Zha HW, Liu ZJ, Wang MM, Zhang YQ, Bi JR, Wu TY, Liu ZJ, Wu H, Sun D.   +9 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Parkinson's Disease: Biomarkers for Diagnosis and Disease Progression. [PDF]

Int J Mol Sci
Arya R, Haque AKMA, Shakya H, Billah MM, Parvin A, Rahman MM, Sakib KM, Faruquee HM, Kumar V, Kim JJ.   +9 more
europepmc   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Immune Regulation and Disulfidptosis in Atherosclerosis Influence Disease Progression and Therapy. [PDF]

Biomedicines
Lu W, Zhang Z, Qiao G, Zou G, Li G.
europepmc   +1 more source

Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report. [PDF]

Respir Med Case Rep
Tanaka T, Takahara Y, Abe R, Sumito N, Ishige Y, Shionoya I, Yamamura K, Nojiri M, Iguchi M.   +8 more
europepmc   +1 more source